A pathway-based approach investigating DNA sequence variants to implicate the inflammatory pathway in the predisposition to Achilles tendinopathy

The aims of this dissertation were therefore (i) to follow a pathway-based approach investigating genes encoding proteins involved in the ECM degradation and apoptosis signalling cascade for associations with AT and (ii) to identify a polygenic risk model, comprised of several genetic markers within genes encoding proteins involved in the inflammatory pathway, to predict risk of AT.

Grantor dc:publisher.institution

MRC/UCT RU for Exercise and Sport Medicine

Year dc:date.issued

2011

Author dc:creator

• Nell, Erica-Mari

Advisor dc:contributor.advisor

• September, Alison

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/10807

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/10807