Evaluation of new diagnostic and treatment strategies in the management of the Zollinger-Ellison syndrome

Despite major advances over the last two decades with the management of patients with Zollinger-Ellison syndrome (ZES), unanswered questions remain concerning the natural history of the disease, the impact of new diagnostics modalities on cure rates, and the role of surgery in the era of modem medical therapies. The aims of the thesis are to (i) analyse the database of 40 ZES patients treated at Groote Schuur Hospital (GSH) over two decades, with special reference to the impact of various surgical strategies on outcome, (ii) investigate a possible correlation between biological tissue marker expression and tumour behaviour, (iii) study the effect of somatostatin receptor scintigraphy (SRS) on surgical cure rates, and (iv) assess the efficacy and safety of a new proton pump inhibitor (pantoprazole) in controlling acid hypersecretion.

Grantor dc:publisher.institution

Department of Surgery

Year dc:date.issued

2000

Author dc:creator

• Radebold, Klaus

Advisor dc:contributor.advisor

• Bornman, PC

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/10762

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/10762