Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"proton pump"”.
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Do proton pump inhibitors reduce the incidence of pharyngocutaneous fistulae following total laryngectomy?
… laryngectomy. We hypothesised that perioperative proton pump inhibitor (PPI) treatment could reduce the incidence of pharyngocutaneous fistulae. This prospective placebo-controlled double-blind randomised controlled trial compared PPI treatment (14 days enteral omeprazole) with a placebo in …
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Digesting the role of the gut microbiome in proton pump inhibitor (PPI)-induced hypomagnesemia
Contains fulltext : 233371 .pdf (Publisher’s version ) (Open Access)
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Utilization of Proton Pump Inhibitors in Combination Regimen for Breast Cancer Treatment by Targeting Fatty Acid Synthase
… (NHEJ) repair of DNA double-strand break. Proton pump inhibitors (PPIs), were originally designed to decrease gastric acid production by binding irreversibly with gastric hydrogen potassium ATPase. PPIs have recently been reported to reduce drug resistance in cancer cells when used in …
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Novel mechanism of gastric proton pump inhibitor (PPI) : Suppression of Helicobacter-pylori induced angiogenesis and selective induction of apoptosis in gastric cancer cells.
… a lower extracellular pH, ability to up-regulate proton extrusion is critical for cancer cell survival. Gastric H+/K+-ATPase exchanges luminal K+ for cytoplasmic H+ and is the enzyme primarily responsible for gastric acidification. On the basis of the fact that blocking the clearance of acidic …
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Fourier transform infrared difference spectroscopy of bacteriorhodopsin
… spectroscopy to study the photocycle and proton pump of bacteriorhodopsin (bR). By applying this method to the study of native bR and bR with modified chromophores, we have confirmed and extended the earlier resonance Raman results concerning the configuration of the chromophore of bR and …
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Protonų siurblio inhibitorių suvartojimo tyrimas Lietuvoje 2022 metais /
… thesis topic: Research on the Consumption of Proton Pump Inhibitors in Lithuania in 2022. The aim of the research: Based on electronic prescriptions issued in 2022, to analyze the trends in the use of proton pump inhibitors in Lithuania according to age, indications and municipalities. Tasks …
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Proton-atpase in fish gills
The cellular mechanisms responsible for branchial proton excretion and sodium absorption in freshwater rainbow trout, Oncorhynchus mykiss (Walbaum), were investigated by monitoring the proton excretion rate and determining the proton ATPase activity in gill tissue under different inhibitor …
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Epidemiological investigations of liver cancer: biomarkers, reproductive factors and modifiable risk factors:
… by serum ferritin or serum iron. <br/><br/>Proton pump inhibitors and histamine-2 receptor antagonists are commonly used. Proton pump inhibitors have been shown to promote liver cancer in rats; however, only one study has examined the association in humans. We conducted the first study on …
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Proton release and the photocycle of bacteriorhodopsin
Bacteriorhodopsin (bR) is a light-driven proton pump. Over the last several years, much has been done in determining the structure and function of this protein; however, the exact mechanism of the proton pump is still unknown. My work presented here focuses on characterizing the proton release …
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Evaluation of new diagnostic and treatment strategies in the management of the Zollinger-Ellison syndrome
… and (iv) assess the efficacy and safety of a new proton pump inhibitor (pantoprazole) in controlling acid hypersecretion.
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Examining the effect of anti-tumor lipid drugs on pH homeostasis and membrane structure in Saccharomyces cerevisiae
… resulting in the internalization of essential proton pump, Pma1 and ergosterol. To further elucidate the conditions that enhance or prevent the cytotoxic effect of edelfosine, genome-wide surveys in the model organism Saccharomyces cerevisiae were performed. The results of these screens …
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AcidopHiles : a not- so-basic life
… a number of methods, including a highly active proton pump, or five-ring structures called hopanoids that are imbedded in the cell membrane, among others. Acidophiles can be applied to many human questions. They are used in the process of bioremediation as applied to acid mine drainage sites. …
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Development of next-generation optical neural silencers
… The expression of light-driven ion channels and pumps allows these pathways to be observed, mapped and controlled with millisecond timescale resolution. We here show that it is possible to mediate the powerful multiple-color silencing of neural activity through the heterologous expression of …
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AIRWAY SURFACE HYPERVISCOSITY AND DEFECTIVE MUCOCILIARY TRANSPORT BY IL-17/TNF-ALPHA ARE CORRECTED BY BETA-ADRENERGIC STIMULUS
… showed upregulation of ENaC channel, ATP12A proton pump, ADRB2 β-adrenergic receptor, and SLC26A4 anion exchanger. The overall result of IL-17A/TNF-α treatment was hyperviscosity of the airway surface, as demonstrated by fluorescence recovery after photobleaching (FRAP) experiments. …
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Study of the Proton Pumping Mechanism of the Aa3-Type Cytochrome C Oxidase
… followed by stepwise reduction, requiring four protons and four electrons. These four protons are taken up from the negative (N) side of the membrane through two proton conductive channels (D-channel and K-channel). C cO is also a redox-driven proton pump, i.e., the free energy produced by …
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Molecular dynamics studies of membranes and membrane proteins
… Three systems were investigated: (1) The proton pump cycle of the integral membrane protein bacteriorhodopsin: The photoisomerization and subsequent thermal reactions of the protein were studied by molecular dynamics simulations. Internal water molecules were placed in the protein. The …
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Genomics research and cultivating serendipity in pharmaceutical drug discovery : assessing the competitiveness of R&D productivity between the West and Asia
… drugs on the market, ranging from statins to proton-pump inhibitors (PPIs).
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Physiological effects of heterologous expression of proteorhodopsin photosystems
… for producing a functional light-driven proton pump, capable of powering cellular processes. This thesis describes the functional characterization of a subcloned PRPS previously identified from a large insert metagenomic library (Martinez et al., 2007). Incorporation of the PRPS into a …
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Probiotic Use in Trauma Patients: A Pathway to Determining the Standard of Care to Improve Outcomes
… These include treatment with antibiotics, proton pump inhibitors, and opioids as well as therapies that require invasive procedures and monitoring. One suggested means to restore immune function and for the prevention of HAIs is to supplement patients with probiotics to restore or replenish …
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Light-induced currents from oriented purple membrane
… high, the microsecond component represents a proton release signal; (2) when the salt (or buffer) concentration is relatively low, the microsecond photocurrent component represents a sum of proton release and metallic cations (or protonated pH buffer molecules) moving backwards in the …
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