Using finite element models under multiple loading conditions to improve the association between radius and tibia microarchitecture and prevalent osteoporotic vertebral fracture

Bone microarchitecture differences at the tibia and radius, measurable by high-resolution peripheral quantitative computed tomography (HR-pQCT) exist between individuals with a prevalent vertebral fracture and healthy controls. As fracture is a result of mechanical failure, FE models of these sites in physiologically relevant loading conditions (compression, torsion, bending) may reveal insight into fracture pathogenesis uncaptured by microarchitecture. In this study, HR-pQCT scans at the tibia and radius were collected from post-menopausal women with prevalent vertebral fracture and healthy controls, from which microarchitecture and finite element outcomes (Pistoia failure load, apparent modulus) were calculated. At the tibia, a one standard deviation increase in compressive failure load was most strongly associated with fracture risk reduction (OR= 0.369, p=0.002), followed by compressive apparent modulus (OR= 0.473, p=0.010), torsion apparent modulus (OR= 0.493, p=0.023), and bending apparent modulus (OR=0.550, p=0.010). At the radius, failure load was the only FE outcome associated with fracture risk reduction (OR=0.534, p=0.023). None of the FE outcomes improved fracture discrimination compared to measures of bone microarchitecture. This study demonstrates the applicability of using FE under multiple loading conditions to evaluate bone structure changes related to osteoporotic fracture.

Name thesis:degree_name

Master of Science (MSc)

Discipline thesis:degree_discipline

Biomedical Engineering

Grantor dc:publisher.institution

Cumming School of Medicine

Year dc:date.issued

2018

Author dc:creator

• George, Jacob Koshy

Advisor dc:contributor.advisor

• Boyd, Steven Kyle

Committee members dc:contributor.committeemember

• Kuo, Arthur D.
• Duncan, Neil A.

• Finite Element Analysis
• HR-pQCT
• fracture
• bone microarchitecture

Statement dc:rights

• University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.

Language dc:language.iso

eng

DOI

http://dx.doi.org/10.11575/PRISM/31976

OAI identifier oai:identifier

oai:ucalgary.scholaris.ca:1880/106748