{"id":{"repo_id":"calgary","oai_identifier":"oai:ucalgary.scholaris.ca:1880/106748"},"canonical_url":"https://search.dev.ndltd.org/etd/calgary/oai:ucalgary.scholaris.ca:1880/106748","repository":{"repo_id":"calgary","name":"University of Calgary","base_url":"https://ucalgary.scholaris.ca/server/oai/request"},"display":{"title":"Using finite element models under multiple loading conditions to improve the association between radius and tibia microarchitecture and prevalent osteoporotic vertebral fracture","abstract":"Bone microarchitecture differences at the tibia and radius, measurable by high-resolution peripheral quantitative computed tomography (HR-pQCT) exist between individuals with a prevalent vertebral fracture and healthy controls. As fracture is a result of mechanical failure, FE models of these sites in physiologically relevant loading conditions (compression, torsion, bending) may reveal insight into fracture pathogenesis uncaptured by microarchitecture. In this study, HR-pQCT scans at the tibia and radius were collected from post-menopausal women with prevalent vertebral fracture and healthy controls, from which microarchitecture and finite element outcomes (Pistoia failure load, apparent modulus) were calculated. At the tibia, a one standard deviation increase in compressive failure load was most strongly associated with fracture risk reduction (OR= 0.369, p=0.002), followed by compressive apparent modulus (OR= 0.473, p=0.010), torsion apparent modulus (OR= 0.493, p=0.023), and bending apparent modulus (OR=0.550, p=0.010). At the radius, failure load was the only FE outcome associated with fracture risk reduction (OR=0.534, p=0.023). None of the FE outcomes improved fracture discrimination compared to measures of bone microarchitecture. This study demonstrates the applicability of using FE under multiple loading conditions to evaluate bone structure changes related to osteoporotic fracture.","abstract_html":"Bone microarchitecture differences at the tibia and radius, measurable by high-resolution peripheral quantitative computed tomography (HR-pQCT) exist between individuals with a prevalent vertebral fracture and healthy controls. As fracture is a result of mechanical failure, FE models of these sites in physiologically relevant loading conditions (compression, torsion, bending) may reveal insight into fracture pathogenesis uncaptured by microarchitecture. In this study, HR-pQCT scans at the tibia and radius were collected from post-menopausal women with prevalent vertebral fracture and healthy controls, from which microarchitecture and finite element outcomes (Pistoia failure load, apparent modulus) were calculated. At the tibia, a one standard deviation increase in compressive failure load was most strongly associated with fracture risk reduction (OR= 0.369, p=0.002), followed by compressive apparent modulus (OR= 0.473, p=0.010), torsion apparent modulus (OR= 0.493, p=0.023), and bending apparent modulus (OR=0.550, p=0.010). At the radius, failure load was the only FE outcome associated with fracture risk reduction (OR=0.534, p=0.023). None of the FE outcomes improved fracture discrimination compared to measures of bone microarchitecture. This study demonstrates the applicability of using FE under multiple loading conditions to evaluate bone structure changes related to osteoporotic fracture.","abstract_has_math":false,"creators":["George, Jacob Koshy"],"institution":"Cumming School of Medicine","degree_name":"Master of Science (MSc)","degree_level":null,"degree_discipline":"Biomedical Engineering","degree_department":null,"school":null,"contributors":[],"advisors":["Boyd, Steven Kyle"],"committee_chairs":[],"committee_members":["Kuo, Arthur D.","Duncan, Neil A."],"year":2018,"date_issued":"2018-05-31","date_published":"2018-05-31","updated_at":"2026-07-24T01:30:15Z","subjects":["Finite Element Analysis","HR-pQCT","fracture","bone microarchitecture"],"languages":["eng"],"rights":["University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission."],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.doi","label":"DOI","values":["http://dx.doi.org/10.11575/PRISM/31976"],"render_values":[{"text":"http://dx.doi.org/10.11575/PRISM/31976","href":"http://dx.doi.org/10.11575/PRISM/31976","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/1880/106748","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Boyd, Steven Kyle"]},{"key":"dc:contributor.committeemember","label":"Committee Member","values":["Kuo, Arthur D.","Duncan, Neil A."]},{"key":"dc:creator","label":"Author","values":["George, Jacob Koshy"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2018-11"]},{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2018-06-08T20:44:56Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2018-06-08T20:44:56Z"]},{"key":"dc:date.issued","label":"Date","values":["2018-05-31"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Calgary"]},{"key":"dc:type","label":"Dc Type","values":["master thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biomedical Engineering"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (MSc)"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Calgary"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Finite Element Analysis","HR-pQCT","fracture","bone microarchitecture"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.doi","label":"DOI","values":["http://dx.doi.org/10.11575/PRISM/31976"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/1880/106748"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Bone microarchitecture differences at the tibia and radius, measurable by high-resolution peripheral quantitative computed tomography (HR-pQCT) exist between individuals with a prevalent vertebral fracture and healthy controls. As fracture is a result of mechanical failure, FE models of these sites in physiologically relevant loading conditions (compression, torsion, bending) may reveal insight into fracture pathogenesis uncaptured by microarchitecture. In this study, HR-pQCT scans at the tibia and radius were collected from post-menopausal women with prevalent vertebral fracture and healthy controls, from which microarchitecture and finite element outcomes (Pistoia failure load, apparent modulus) were calculated. At the tibia, a one standard deviation increase in compressive failure load was most strongly associated with fracture risk reduction (OR= 0.369, p=0.002), followed by compressive apparent modulus (OR= 0.473, p=0.010), torsion apparent modulus (OR= 0.493, p=0.023), and bending apparent modulus (OR=0.550, p=0.010). At the radius, failure load was the only FE outcome associated with fracture risk reduction (OR=0.534, p=0.023). None of the FE outcomes improved fracture discrimination compared to measures of bone microarchitecture. This study demonstrates the applicability of using FE under multiple loading conditions to evaluate bone structure changes related to osteoporotic fracture."]},{"key":"dc:title","label":"Title","values":["Using finite element models under multiple loading conditions to improve the association between radius and tibia microarchitecture and prevalent osteoporotic vertebral fracture"]}]}],"canonical_facts":{"dc:contributor.advisor":["Boyd, Steven Kyle"],"dc:contributor.committeemember":["Kuo, Arthur D.","Duncan, Neil A."],"dc:creator":["George, Jacob Koshy"],"dc:date":["2018-11"],"dc:date.accessioned":["2018-06-08T20:44:56Z"],"dc:date.available":["2018-06-08T20:44:56Z"],"dc:date.issued":["2018-05-31"],"dc:description.abstract":["Bone microarchitecture differences at the tibia and radius, measurable by high-resolution peripheral quantitative computed tomography (HR-pQCT) exist between individuals with a prevalent vertebral fracture and healthy controls. As fracture is a result of mechanical failure, FE models of these sites in physiologically relevant loading conditions (compression, torsion, bending) may reveal insight into fracture pathogenesis uncaptured by microarchitecture. In this study, HR-pQCT scans at the tibia and radius were collected from post-menopausal women with prevalent vertebral fracture and healthy controls, from which microarchitecture and finite element outcomes (Pistoia failure load, apparent modulus) were calculated. At the tibia, a one standard deviation increase in compressive failure load was most strongly associated with fracture risk reduction (OR= 0.369, p=0.002), followed by compressive apparent modulus (OR= 0.473, p=0.010), torsion apparent modulus (OR= 0.493, p=0.023), and bending apparent modulus (OR=0.550, p=0.010). At the radius, failure load was the only FE outcome associated with fracture risk reduction (OR=0.534, p=0.023). None of the FE outcomes improved fracture discrimination compared to measures of bone microarchitecture. This study demonstrates the applicability of using FE under multiple loading conditions to evaluate bone structure changes related to osteoporotic fracture."],"dc:identifier.doi":["http://dx.doi.org/10.11575/PRISM/31976"],"dc:identifier.uri":["http://hdl.handle.net/1880/106748"],"dc:language.iso":["eng"],"dc:publisher.institution":["University of Calgary"],"dc:rights":["University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission."],"dc:subject":["Finite Element Analysis","HR-pQCT","fracture","bone microarchitecture"],"dc:title":["Using finite element models under multiple loading conditions to improve the association between radius and tibia microarchitecture and prevalent osteoporotic vertebral fracture"],"dc:type":["master thesis"],"thesis:degree_discipline":["Biomedical Engineering"],"thesis:degree_name":["Master of Science (MSc)"],"thesis:institution_name":["University of Calgary"]},"updated_at":"2026-07-24T01:30:15Z"}