Predictors of Response to Repetitive Transcranial Magnetic Stimulation Treatment in Adolescent Major Depressive Disorder

Adolescent major depressive disorder has limited treatment options and response is unpredictable. Repetitive transcranial magnetic stimulation (rTMS) is a novel treatment option while pre-treatment cortical thickness may be an objective biomarker predictive of response. Twenty-three youth (12-21 years; 11 female) with treatment-resistant depression (TRD) underwent 3 weeks of high-frequency rTMS. Baseline left rostral middle frontal gyrus (lRMF) thickness was compared between eventual responders, non-responders and age-matched controls (n=16; 10 female). Symptom-specific treatment response, defined as ≥50% symptom reduction, was evaluated. Demographic and symptom profile differences were explored. Interventional rTMS alleviated both anxious and depressive symptoms. lRMF was thinner in responders than non-responders, and age negatively correlated with lRMF thickness in controls but not TRD subjects. Exploration of demographic and symptom variables showed responders on the depressive measure had greater frequency of past suicide attempts and higher atypical symptom cluster score while social phobia was associated with non-responsiveness.

Name thesis:degree_name

Master of Science (MSc)

Discipline thesis:degree_discipline

Neuroscience

Grantor dc:publisher.institution

Cumming School of Medicine

Year dc:date.issued

2018

Author dc:creator

• McLellan, Quinn Kenneth

Advisor dc:contributor.advisor

• MacMaster, Frank P.

Committee members dc:contributor.committeemember

• Arnold, Paul Daniel
• Bulloch, Andrew G. M.

• adolescent
• Major depressive disorder
• repetitive transcranial magnetic stimulation
• neuroimaging
• biomarkers
• predictors of response

Statement dc:rights

• University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.

Language dc:language.iso

eng

DOI

http://dx.doi.org/10.11575/PRISM/31859

OAI identifier oai:identifier

oai:ucalgary.scholaris.ca:1880/106573