Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"predictors of response"”.
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Predictors of Response to Acetylcholinesterase Inhibitors: An Observational Case Register-Based Cohort Study
… inhibitors (AChEIs) are a key component of dementia care. Longitudinal cognitive change in patients before and after AChEI initiation has never been described previously, although individual responses have been described as heterogeneous. Predictors of such responses are not well …
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Predictors of Response to Repetitive Transcranial Magnetic Stimulation Treatment in Adolescent Major Depressive Disorder
… disorder has limited treatment options and response is unpredictable. Repetitive transcranial magnetic stimulation (rTMS) is a novel treatment option while pre-treatment cortical thickness may be an objective biomarker predictive of response. Twenty-three youth (12-21 years; 11 female) with …
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Immune parameters as predictors of response to maintenance therapy in low grade non-Hodgkin's lymphoma patients
… lymphomas (NHL) are a heterogeneous group of malignancies characterised by the uncontrolled proliferation of lymphoid cells. The Working Formulation divides these neoplasms into low, intermediate and high-grade categories according to their natural history. Low grade NHL (LG-NHL) is …
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Clinical, Metabolic and Inflammatory Indicators of Esketamine Efficacy for Treatment-Resistant Major Depressive Episodes
… with treatment-resistant depression (TRD) often experience severe symptoms and elevated suicide risk. Metabolic and inflammatory abnormalities may contribute to inadequate response to treatments. Esketamine has demonstrated promise in TRD, but its biological effects and predictors of …
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Predicting mental health provider response to BREATHE, a burnout intervention program
… that were hypothesized to be predictive of response to BREATHE, a burnout intervention for mental health providers. Data from four prior studies that assessed the effectiveness of the BREATHE intervention were amalgamated. For the primary analyses, hierarchical linear regression was used …
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An Analysis of Differential Responses to Racism
… Americans reported social discrimination more often than other ethnic groups and African Americans reported discrimination in service and police incidents more often than other ethnic groups. Also, African Americans responded to racism with confrontation more than other ethnic groups, and …
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The Efficacy of Melodic Based Communication Therapy for Eliciting Speech in Nonverbal Children with Autism
<p>The purpose of this dissertation is to compare the efficacy of Melodic Based Communication Therapy (MBCT) to traditional speech and language therapy for eliciting speech in nonverbal children with autism. Efficacy was assessed by number of: verbalizations, correct words, words reported by …
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Determinants and Monitoring of Response to Disease-Modifying Therapy for Transthyretin Amyloidosis Cardiomyopathy: The ATTR-CM Therapy Study
… muscle disease characterized by the accumulation of misfolded transthyretin proteins as amyloid plaques in the myocardial interstitium. In 2020, tafamidis, a medication inhibiting the misfolding of transthyretin, received Health Canada's approval for treating ATTR-CM. However, substantial …
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Variability in Exercise Responsiveness Among Older Adults: An Examination of Predictors and Patterns of Nonresponse to Exercise in Peripheral Artery Disease
… variability observed in outcomes of aerobic exercise programs among older adults, little is known about the prevalence of nonresponse to exercise in this population. Supervised exercise therapy (SET) is the primary guideline-recommended therapy for the treatment of symptomatic …
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The clonal architecture and tumour microenvironment of breast cancers are shaped by neoadjuvant chemotherapy
… early breast cancer as it improves rates of breast conservation surgery and enables prediction of recurrence and survival by using response to treatment as a surrogate. Previous studies have focused on generating molecular datasets to develop prediction models of response, though little is …
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Quantitative Magnetic Resonance Imaging For The Early Prediction of Treatment Response In Triple Negative Breast Cancer
… Breast Cancer (TNBC) is an aggressive subtype of breast cancer which lacks upregulated hormone receptors. Because of this, it is not vulnerable to clinically available targeted therapies. When treated with standard of care neoadjuvant systemic therapy (NAST), TNBC only shows approximately a 40% …
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Impact of Intratumor Heterogeneity and The Tumor Microenvironment In Shaping Tumor Evolution and Response to Therapy
… variation, which may result in mixed or failed response to therapy. The heterogeneity at the tumor level, along with the tumor microenvironment (TME), often shapes tumor evolution and ultimately clinical outcome. Given that modern treatment paradigms increasingly expose patients with metastatic …