Abstract
dc:description.abstractMultiple seizures cause changes to both cortical movement representations (motor maps) and behavioural impairment. The contribution of seizures to motor map alterations and impaired skilled forelimb movement was studied using the electrical kindling model and short-duration intracortical microstimulation (SD-ICMS). Forelimb motor map movements changed considerably from contralateral in sham-kindled rats to ipsilateral and bilateral in rats kindled for over 5 sessions. Furthermore, bilateral movement representations were related to impairments in skilled forelimb subcomponents. Finally, skilled forelimb impairment was also related to the number of bilateral seizures experienced as well as the duration of bilateral seizures. Next, the role of the ipsilateral hemisphere in bilateral movement representations was examined using SD-ICMS and reversible cooling inactivation. Bilateral representations were produced using electrical kindling as well as pharmacological HCN channel blocker ZD7288. Inactivating the cortex ipsilateral to the skilled forelimb completely eliminated ipsilateral and bilateral movement, indicating its role in bilateral movement representations.
Degree
thesis:*- Name thesis:degree_name
- Master of Science (MSc)
- Discipline thesis:degree_discipline
- Psychology
- Grantor dc:publisher.institution
- Graduate Studies
- Year dc:date.issued
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Rodych, Justin
- Advisor dc:contributor.advisor
-
- Teskey, Campbell
Subjects
dc:subject × 2Rights
dc:rights- Statement dc:rights
-
- University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
- Language dc:language.iso
- eng
Identifiers
dc:identifier.*- OAI identifier oai:identifier
- oai:ucalgary.scholaris.ca:11023/2606