The KATP -Knockout Mouse: A Model of Susceptibility to Post-Concussion Syndrome

Approximately 1.4 million people in the United States each year sustain a mild traumatic brain injury (mTBI). Unfortunately, approximately 15% of these patients will have post- concussive symptoms that last longer than three months. Knowledge of the pathophysiological processes underlying susceptibility to poor outcomes is limited, which has impaired the development of effective therapeutics for patients with a mTBI. The present study was designed to assess behavioral and molecular changes post-mTBI in an animal model of genetic susceptibility to poor neurological outcomes, the Kir6.2-knockout mouse. We conducted multiple behavioral tests and analyzed the cellular stress response through assessment of heat shock protein (Hsps) gene expression. We hypothesized that following mTBI, Kir6.2-knockout mice would have increased behavioral deficits, and aberrant Hsp expression. Results from behavioral and molecular analyses demonstrated that outcomes post-mTBI depended on sex and genetic make-up, and that the influence of these factors changed throughout the recovery process.

Name thesis:degree_name

Master of Science (MSc)

Discipline thesis:degree_discipline

Neuroscience

Grantor dc:publisher.institution

Graduate Studies

Year dc:date.issued

2014

Author dc:creator

• Farran, Allyson

Advisor dc:contributor.advisor

• Esser, Michael

• Neuroscience

Statement dc:rights

• University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.

Language dc:language.iso

eng

DOI

http://dx.doi.org/10.11575/PRISM/28226

OAI identifier oai:identifier

oai:ucalgary.scholaris.ca:11023/1933