The Influence of Maximal and Submaximal Cyclic Concentric and Eccentric Exercise on Chondrocyte Death and Synovial Fluid Proteins in the Rabbit knee

Excessive joint loading has been associated with the onset and an increased rate of progression of osteoarthritis, but little is known about the effects of exercise loading on synovial fluid (SF) composition and chondrocytes viability. The purpose of this study was to load intact knee joints with two types of controlled maximal muscular contractions (low, and high intensity exercise) and identify changes in synovial fluid protein composition and chondrocyte death. We found that: 1. Chondrocytes are well protected to withstand very high loads over a short period of time, and maximal endurance loading. 2. High intensity, short duration exercise did not change total protein concentration in SF. However, it decreased the number of identifiable proteins. 3. Low intensity, long duration exercise did not change total protein concentration in the SF, but it increased the number of identifiable proteins.

Name thesis:degree_name

Master of Science (MSc)

Discipline thesis:degree_discipline

Biomedical Engineering

Grantor dc:publisher.institution

Graduate Studies

Year dc:date.issued

2014

Author dc:creator

• Abughazaleh, Nada

Advisor dc:contributor.advisor

• Herzog, Walter

• Engineering--Biomedical

Statement dc:rights

• University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.

Language dc:language.iso

eng

DOI

http://dx.doi.org/10.11575/PRISM/28212

OAI identifier oai:identifier

oai:ucalgary.scholaris.ca:11023/1673