{"id":{"repo_id":"calgary","oai_identifier":"oai:ucalgary.scholaris.ca:11023/1673"},"canonical_url":"https://search.dev.ndltd.org/etd/calgary/oai:ucalgary.scholaris.ca:11023/1673","repository":{"repo_id":"calgary","name":"University of Calgary","base_url":"https://ucalgary.scholaris.ca/server/oai/request"},"display":{"title":"The Influence of Maximal and Submaximal Cyclic Concentric and Eccentric Exercise on Chondrocyte Death and Synovial Fluid Proteins in the Rabbit knee","abstract":"Excessive joint loading has been associated with the onset and an increased rate of progression of osteoarthritis, but little is known about the effects of exercise loading on synovial fluid (SF) composition and chondrocytes viability. The purpose of this study was to load intact knee joints with two types of controlled maximal muscular contractions (low, and high intensity exercise) and identify changes in synovial fluid protein composition and chondrocyte death. We found that: 1. Chondrocytes are well protected to withstand very high loads over a short period of time, and maximal endurance loading. 2. High intensity, short duration exercise did not change total protein concentration in SF. However, it decreased the number of identifiable proteins. 3. Low intensity, long duration exercise did not change total protein concentration in the SF, but it increased the number of identifiable proteins.","abstract_html":"Excessive joint loading has been associated with the onset and an increased rate of progression of osteoarthritis, but little is known about the effects of exercise loading on synovial fluid (SF) composition and chondrocytes viability. The purpose of this study was to load intact knee joints with two types of controlled maximal muscular contractions (low, and high intensity exercise) and identify changes in synovial fluid protein composition and chondrocyte death. We found that: 1. Chondrocytes are well protected to withstand very high loads over a short period of time, and maximal endurance loading. 2. High intensity, short duration exercise did not change total protein concentration in SF. However, it decreased the number of identifiable proteins. 3. Low intensity, long duration exercise did not change total protein concentration in the SF, but it increased the number of identifiable proteins.","abstract_has_math":false,"creators":["Abughazaleh, Nada"],"institution":"Graduate Studies","degree_name":"Master of Science (MSc)","degree_level":null,"degree_discipline":"Biomedical Engineering","degree_department":null,"school":null,"contributors":[],"advisors":["Herzog, Walter"],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-08-07","date_published":"2014-08-07","updated_at":"2026-07-24T01:30:20Z","subjects":["Engineering--Biomedical"],"languages":["eng"],"rights":["University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission."],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.doi","label":"DOI","values":["http://dx.doi.org/10.11575/PRISM/28212"],"render_values":[{"text":"http://dx.doi.org/10.11575/PRISM/28212","href":"http://dx.doi.org/10.11575/PRISM/28212","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/11023/1673","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Herzog, Walter"]},{"key":"dc:creator","label":"Author","values":["Abughazaleh, Nada"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-08-07T20:39:30Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-11-17T08:00:40Z"]},{"key":"dc:date.issued","label":"Date","values":["2014-08-07"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Calgary"]},{"key":"dc:type","label":"Dc Type","values":["master thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biomedical Engineering"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (MSc)"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Calgary"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Engineering--Biomedical"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["University of Calgary graduate students retain copyright ownership and moral rights for their thesis. 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The purpose of this study was to load intact knee joints with two types of controlled maximal muscular contractions (low, and high intensity exercise) and identify changes in synovial fluid protein composition and chondrocyte death. We found that: 1. Chondrocytes are well protected to withstand very high loads over a short period of time, and maximal endurance loading. 2. High intensity, short duration exercise did not change total protein concentration in SF. However, it decreased the number of identifiable proteins. 3. Low intensity, long duration exercise did not change total protein concentration in the SF, but it increased the number of identifiable proteins."]},{"key":"dc:title","label":"Title","values":["The Influence of Maximal and Submaximal Cyclic Concentric and Eccentric Exercise on Chondrocyte Death and Synovial Fluid Proteins in the Rabbit knee"]}]}],"canonical_facts":{"dc:contributor.advisor":["Herzog, Walter"],"dc:creator":["Abughazaleh, Nada"],"dc:date.accessioned":["2014-08-07T20:39:30Z"],"dc:date.available":["2014-11-17T08:00:40Z"],"dc:date.issued":["2014-08-07"],"dc:description.abstract":["Excessive joint loading has been associated with the onset and an increased rate of progression of osteoarthritis, but little is known about the effects of exercise loading on synovial fluid (SF) composition and chondrocytes viability. The purpose of this study was to load intact knee joints with two types of controlled maximal muscular contractions (low, and high intensity exercise) and identify changes in synovial fluid protein composition and chondrocyte death. We found that: 1. Chondrocytes are well protected to withstand very high loads over a short period of time, and maximal endurance loading. 2. High intensity, short duration exercise did not change total protein concentration in SF. However, it decreased the number of identifiable proteins. 3. Low intensity, long duration exercise did not change total protein concentration in the SF, but it increased the number of identifiable proteins."],"dc:identifier.doi":["http://dx.doi.org/10.11575/PRISM/28212"],"dc:identifier.uri":["http://hdl.handle.net/11023/1673"],"dc:language.iso":["eng"],"dc:publisher.institution":["University of Calgary"],"dc:rights":["University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission."],"dc:subject":["Engineering--Biomedical"],"dc:title":["The Influence of Maximal and Submaximal Cyclic Concentric and Eccentric Exercise on Chondrocyte Death and Synovial Fluid Proteins in the Rabbit knee"],"dc:type":["master thesis"],"thesis:degree_discipline":["Biomedical Engineering"],"thesis:degree_name":["Master of Science (MSc)"],"thesis:institution_name":["University of Calgary"]},"updated_at":"2026-07-24T01:30:20Z"}