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Università degli Studi di Cagliari
Development of novel reactive oxygen species (ROS)-modulating agents and carbonic anhydrase inhibitors for the treatment of Pancreatic Ductal Adenocarcinoma and other resistant cancers
Abstract
dc:descriptionIn the present PhD thesis I propose the study and pharmacobiological optimization of a class of quinazolin-5,8-dione-based (QDs) compounds that showed promising antitumor activity against pancreatic ductal adenocarcinoma (PDAC) as well as other tumor types. In the same context of developing new active compounds against resistant cancer forms, I propose the study of a novel class of selective carbonic anhydrase inhibitors (CAI) targeting the human isoforms IX and XII (hCA IX and XII) overexpressed in several cancer types. Additionally, I propose the development of a serie of multivalent inhibitors designed to optimize both selectivity and potency against different hCA isoforms.
Degree
thesis:*- Grantor dc:publisher
- Università degli Studi di Cagliari
- Year dc:date
- 2025
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- LADU, FEDERICO
Subjects
dc:subject × 1Rights
dc:rights- Statement dc:rights
-
- info:eu-repo/semantics/embargoedAccess
- Language dc:language
- eng
Identifiers
dc:identifier.*- Handle dc:identifier
- https://hdl.handle.net/11584/449468
- OAI identifier oai:identifier
- oai:iris.unica.it:11584/449468