Development of novel reactive oxygen species (ROS)-modulating agents and carbonic anhydrase inhibitors for the treatment of Pancreatic Ductal Adenocarcinoma and other resistant cancers
type: CreativeWork
description: In the present PhD thesis I propose the study and pharmacobiological optimization of a class of quinazolin-5,8-dione-based (QDs) compounds that showed promising antitumor activity against pancreatic ductal adenocarcinoma (PDAC) as well as other tumor types. In the same context of developing new active compounds against resistant cancer forms, I propose the study of a novel class of selective carbonic anhydrase inhibitors (CAI) targeting the human isoforms IX and XII (hCA IX and XII) overexpressed in several cancer types. Additionally, I propose the development of a serie of multivalent inhibitors designed to optimize both selectivity and potency against different hCA isoforms.
abstract: In the present PhD thesis I propose the study and pharmacobiological optimization of a class of quinazolin-5,8-dione-based (QDs) compounds that showed promising antitumor activity against pancreatic ductal adenocarcinoma (PDAC) as well as other tumor types. In the same context of developing new active compounds against resistant cancer forms, I propose the study of a novel class of selective carbonic anhydrase inhibitors (CAI) targeting the human isoforms IX and XII (hCA IX and XII) overexpressed in several cancer types. Additionally, I propose the development of a serie of multivalent inhibitors designed to optimize both selectivity and potency against different hCA isoforms.
author: LADU, FEDERICO
language: eng
keywords: Settore CHIM/08 - Chimica Farmaceutica
date published: 2025-04-29T00:00:00+02:00
date modified: 2026-07-24T01:29:55Z
provider: Università di Cagliari
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Università degli Studi di Cagliari

PropertyValue
property ID: Handle
value: https://hdl.handle.net/11584/449468