Poliaminas em amostras biológicas humanas: importância e métodos de detecção.

Polyamines are basic aliphatic compounds belonging to the list of bioactive amines and have important metabolic and physiological functions in animals, plants and microorganisms . They are an important target for the development of chemotherapy, since they are intimately involved in the processes of growth and cel l replication and its monitoring in biological fluids has been used to estimate the extent of tumor cell death induced by chemotherapy or radiotherapy. In the practice of clinical research , the most widely used methods for the polyamine analysis are chroma tographic methods , particularly high performance liquid chromatography with fluorimetric detection where derivatization is required . The scientific literature provides various pre - analytical methods according to the nature of the clinical samples , blood and urine are being the most used . Furthermore, optimized methods have been developed , particularly those that affect the pH and temperature of the derivatizing reaction , since these two parameters might favor the formation of other detectable products by chromatographic system or lead to decomposition of polyamines respectively, thus compromising the reliability of clinical results .

Grantor dc:publisher

Universidade Federal da Paraíba

Year dc:date.issued

2014

Author dc:creator

• Gomes, Danillo Macêdo.

• Poliaminas
• Cromatografia líquida
• Análises clínicas

Language dc:language.iso

pt

Repository record dc:identifier.uri

https://repositorio.ufpb.br/jspui/handle/123456789/527

OAI identifier oai:identifier

oai:repositorio.ufpb.br:123456789/527