The role of muscle and circulatory microRNAs as regulators and biomarkers of muscle function

Skeletal muscle is an abundant tissue type with critical roles in locomotion, force production and whole body energy regulation. Skeletal muscle mass and function are adaptively regulated by multiple stimuli including physical loading (exercise), nutrient intake (protein supplementation) and lifestyle events (injury and unloading). MicroRNAs (miRNAs) are short non-coding RNAs with the capacity to target specific mRNAs for breakdown and thereby alter the rate and extent of protein expression. Therefore, miRNAs may explain often observed disconnects between gene and protein expression and may regulate key mechanisms underpinning muscle phenotype. The studies in this thesis used a targeted qRT-PCR approach to address the role of muscle regulatory miRNAs in multiple models.

Name thesis:degree_name

PhD

Level thesis:degree_level

Doctoral

Discipline thesis:degree_discipline

Biomedical Science

Grantor dc:publisher

ResearchSpace@Auckland

Year dc:date.issued

2018

Author dc:creator

• D'Souza, Randall

Advisors dc:contributor.advisor

• Mitchell, CJ
• Cameron-Smith, D

Statement dc:rights

• Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.

Licence dc:rights.uri

• https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm

Handle dc:identifier.uri

https://hdl.handle.net/2292/41776

OAI identifier oai:identifier

oai:researchspace.auckland.ac.nz:2292/41776