Abstract
dc:description.abstractThe metabolism of a mixture of [2-14C] and [3',5',7,9-3H]-folic acid was studied in adult male and adult female rats. Both sexes were found to metabolise folic acid to various compounds. Intact folates and catabolites were excreted in the urine and folate polyglutamates were found in the tissues. The extent of tissue uptake and catabolism were found to vary between the male and female rat. Female rats treated with diethylstilboestrol and mazola corn oil showed marked changes in the metabolic handling of folic acid. Less radioactivity was excreted in the urine and catabolism was greatly reduced. There was also a major shift towards 10CHO-folate in the urinary metabolites...
Degree
thesis:*- Name dc:type.qualificationname
- Ph.D.
- Level dc:type.qualificationlevel
- doctoral
- Grantor dc:publisher.institution
- Aston University
- Year dc:date.issued
- 1984
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Guest, Anne E.
Identifiers
dc:identifier.*- DOI dc:identifier.doi
- https://doi.org/10.48780/publications.aston.ac.uk.00011723
- OAI identifier oai:identifier
- oai:publications.aston.ac.uk:11723