{"id":{"repo_id":"aston","oai_identifier":"oai:publications.aston.ac.uk:11723"},"canonical_url":"https://search.dev.ndltd.org/etd/aston/oai:publications.aston.ac.uk:11723","repository":{"repo_id":"aston","name":"Aston University","base_url":"https://publications.aston.ac.uk/cgi/oai2"},"display":{"title":"Studies of Folate Catabolism in the Rat","abstract":"The metabolism of a mixture of [2-14C] and [3',5',7,9-3H]-folic acid was studied in adult male and adult female rats. Both sexes were found to metabolise folic acid to various compounds. Intact folates and catabolites were excreted in the urine and folate polyglutamates were found in the tissues. The extent of tissue uptake and catabolism were found to vary between the male and female rat. Female rats treated with diethylstilboestrol and mazola corn oil showed marked changes in the metabolic handling of folic acid. Less radioactivity was excreted in the urine and catabolism was greatly reduced. There was also a major shift towards 10CHO-folate in the urinary metabolites...","abstract_html":"The metabolism of a mixture of [2-14C] and [3',5',7,9-3H]-folic acid was studied in adult male and adult female rats. Both sexes were found to metabolise folic acid to various compounds. Intact folates and catabolites were excreted in the urine and folate polyglutamates were found in the tissues. The extent of tissue uptake and catabolism were found to vary between the male and female rat. Female rats treated with diethylstilboestrol and mazola corn oil showed marked changes in the metabolic handling of folic acid. Less radioactivity was excreted in the urine and catabolism was greatly reduced. There was also a major shift towards 10CHO-folate in the urinary metabolites...","abstract_has_math":false,"creators":["Guest, Anne E."],"institution":"Aston University","degree_name":"Ph.D.","degree_level":"doctoral","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1984,"date_issued":"1984-05","date_published":"1984-05","updated_at":"2026-07-24T01:01:35Z","subjects":[],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://doi.org/10.48780/publications.aston.ac.uk.00011723","outbound_label":"DOI","outbound_source":"dc:identifier.doi"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Guest, Anne E."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1984-05"]},{"key":"dc:date.issued","label":"Date","values":["1984-05"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Chemical Engineering & Applied Chemistry"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["Aston University"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://publications.aston.ac.uk/id/eprint/11723/"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["Ph.D."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.doi","label":"DOI","values":["10.48780/publications.aston.ac.uk.00011723"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://publications.aston.ac.uk/id/eprint/11723/1/Guest_Anne_Elizabeth_1984_reducded_3056916.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The metabolism of a mixture of [2-14C] and [3',5',7,9-3H]-folic acid was studied in adult male and adult female rats. Both sexes were found to metabolise folic acid to various compounds. Intact folates and catabolites were excreted in the urine and folate polyglutamates were found in the tissues. The extent of tissue uptake and catabolism were found to vary between the male and female rat. Female rats treated with diethylstilboestrol and mazola corn oil showed marked changes in the metabolic handling of folic acid. Less radioactivity was excreted in the urine and catabolism was greatly reduced. There was also a major shift towards 10CHO-folate in the urinary metabolites..."]},{"key":"dc:format","label":"Dc Format","values":["text"]},{"key":"dc:title","label":"Title","values":["Studies of Folate Catabolism in the Rat"]}]}],"canonical_facts":{"dc:creator":["Guest, Anne E."],"dc:date":["1984-05"],"dc:date.issued":["1984-05"],"dc:description.abstract":["The metabolism of a mixture of [2-14C] and [3',5',7,9-3H]-folic acid was studied in adult male and adult female rats. 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