Stimulus-Mitosis Coupling in the Rat Thymic Lymphocyte

Quiescent thymocytes are stimulated to divide by a variety of compounds. These may be subdivided into four categories. The first group includes parathyroid hormone, vitamin D3 and its metabolites and raised extracellular calcium concentrations. Enhanced calcium influx provoked directly or possibly via cGMP production is the prelude to calmodulin activation which subsequently triggers cell arousal by a process which is independent of magnesium ions. High oestradiol concentrations by further increasing intra— cellular calcium concentrations beyond a threshold inhibit this response...

Name dc:type.qualificationname

Ph.D.

Level dc:type.qualificationlevel

doctoral

Grantor dc:publisher.institution

Aston University

Year dc:date.issued

1983

Author dc:creator

• Cade, Christina

DOI dc:identifier.doi

https://doi.org/10.48780/publications.aston.ac.uk.00010554

OAI identifier oai:identifier

oai:publications.aston.ac.uk:10554