Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 75 for “"thymocytes"”.
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Role of Notch Signaling and GATA-3 in Establishing T-lineage Commitment and Survival in Developing Thymocytes
… absolutely required for generation of αβ and γδ thymocytes as well as marginal zone B-cells, while inhibiting B-lineage fate from bone marrow-derived progenitors. Similarly, conditional deletions of GATA-3 establish a profound need for this transcription factor in T-lineage specification for …
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TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes
… in pre-selection CD4+CD8+ (double-positive, DP) thymocytes when stimulated with dextran sulfate (DxS) and explores several candidate channels that may be involved in this rise. . This [Ca2+]i rise is proposed to mimic a physiological mechanism that influences early DP thymocyte selection and …
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TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes
… in pre-selection CD4+CD8+ (double-positive, DP) thymocytes when stimulated with dextran sulfate (DxS) and explores several candidate channels that may be involved in this rise. . This [Ca2+]i rise is proposed to mimic a physiological mechanism that influences early DP thymocyte selection and …
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Immunotoxicity of Pesticide Mixtures and the Role of Oxidative Stress
… pesticide exposure were evaluated. C57BL/6 mouse thymocytes were exposed to lindane, malathion, and permethrin, either separately or in mixtures of two pesticides, in concentrations ranging from 37.5 uM to 1mM. These exposures caused both apoptotic and necrotic cell death in thymocytes as …
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Characterization of Non-Coding RNAs in Regulating Thymic Epithelial Cell Responses to Pathophysiological Stress
… thymus is predominantly composed of developing thymocytes and specialized epithelial cells. The type of stress predicates whether the thymocytes or epithelial cells initiate the involutionary response. MicroRNAs (miRs) are small non-coding RNAs ~18-22 nucleotides in length that maintain cellular …
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An investigation of the role of TRIB2 in steady state and stressed haematopoiesis
… increased proliferation of Trib2-/- developing thymocytes which give rise to increased number of mature thymic subsets. During stressed haematopoiesis, Trib2-/- developing thymocytes demonstrate hypersensitivity to 5-fluorouracil-induced cell death. Nevertheless, Trib2-/- mice exhibit …
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Roles of CTCF and YY1 in T Cell Receptor Gene Rearrangement And T Cell Development
… at the Tcra-Tcrd locus in double-negative thymocytes. Disruption of a discrete chromatin loop encompassing Dδ, Jδ and Cδ gene segments allowed a single Vδ segment to frequently contact and rearrange to diversity and joining gene segments and dominate the adult TCRδ repertoire. Disruption of …
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Immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Diethylstilbestrol (DES) in the Fetal Mouse Thymus and Liver
… flow cytometry, 7-AAD showed decreases in viable thymocytes from TCDD- or DES-treated fetal mice, and concomitant increases in thymocytes in early apoptosis. When thymocytes were co-identified with CD4 and CD8 cell surface antigen expression, enhanced apoptosis occurred in CD4+CD8+ phenotype after …
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Development Of Thymic Natural Killer Cells From Double Negative 1 Thymocyte Precursors
… super>&minus</super>CD8<super>&minus</super>, DN) thymocytes can develop into cells with NK cell markers, but these cells have not been well characterized. Moreover, a subpopulation of NK cells which requires an intact thymus, i.e, thymic NK cells, has been described with selective expression of …
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BTB-Kelch Proteins and TAk1 Kinase N Immune Function
… the maturation of CD4+ or CD8+ single positive thymocytes, leading to reduction of T cells in peripheral tissues. Thymocytes lacking TAK1 failed to activate NF-κB and JNK, and were prone to apoptosis upon stimulation. All three mouse models have provided important evidences in elucidating …
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The Phytoestrogen Genistein Induces Thymic and Immune Changes: A Human Health Concern
… the mechanism of the genistein effect on loss of thymocytes is due in part to increased apoptosis. Genistein injection caused decreases in relative percentages of thymic CD4+CD8- and double-positive CD4+CD8+ thymocytes, providing evidence that genistein may affect early thymocyte maturation and …
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The Role of Epigenetics in Regulating V(D)J Recombination and Allelic Exclusion
… recombination in CD4, CD8 double positive (DP) thymocytes. A previous study had introduced the Tcra enhancer (Eα) into the middle of the Tcrb locus to test if allelic exclusion was mediated solely by RSS accessibility. That study found that Eα could force RSS accessibility in DP …
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Study of the intracellular trafficking of the pre-T-cell receptor and its role in T-cell lineage commitment
… distinct functional lineages. Insight into how thymocytes are nonetheless able to distinguish between these two signals is crucial to our fundamental understanding of T-cell development and how it might be manipulated therapeutically. Pertinently, the pre-TCR is undetectable at the cell surface, …
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Apoptosis as a Mechanism of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-Induced Immunotoxicity
… whether TCDD triggers apoptosis in the thymocytes and whether Fas and Fas ligand play a role in TCDD-mediated immunotoxicity. Administration of a single dose of TCDD at 0.1, 1, 5 or 50 mg/kg body weight intraperitoneally into C57BL/6 +/+ mice caused a significant dose-dependent decrease …
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Chromosomal instability and tumorigenesis : genetic analysis of the murine spindle checkpoint gene Mps1
… MPS1 (MpslA) and induced its expression in thymocytes. I show that MpslA is a partial loss of function allele for spindle checkpoint activation which results in chromosome missegregation in MEFs and embryonic lethality in mice. Expression of MpslA in thymocytes causes sporadic lymphomas and …
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Aspects of T cell development contributing to autoimmunity.
… however observe increased proliferation of CD8+ thymocytes which might contribute to the immune defect in these animals. The impact of thymic insulin expression on development and selection of thymocytes was investigated by using insulin deficient fetal thymi. Analysis by fetal thymic organ …
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Recent Thymic Emigrants and their Biomarkers
… Emigrants. To this extent, nearly egress-ready thymocytes, fully egress-ready thymocytes and naïve PBMCs were obtained from pediatric donors, and both bulk and single cell RNA sequencing was performed to provide insight into the gene expression in these stages of T cell development and obtain …
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Characterization of Stress Responsive MicroRNAs and Their Roles in T Cell Development
… The over-expression of miR-181d in developing thymocytes reduced the number of immature CD4+CD8+ thymocytes. Lipopolysaccharide or dexamethasone injections caused a 4-fold greater loss of these cells than in the wild type controls. The targeted elimination of miR-181d resulted in a thymus …
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Stimulus-Mitosis Coupling in the Rat Thymic Lymphocyte
Quiescent thymocytes are stimulated to divide by a variety of compounds. These may be subdivided into four categories. The first group includes parathyroid hormone, vitamin D3 and its metabolites and raised extracellular calcium concentrations. Enhanced calcium influx provoked directly or possibly …
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On Thymic Regulatory T-Cell Ontogeny
… autoimmunity, the differentiation process of thymocytes is closely supervised by sequential programs, including the rearrangement of T-cell receptor (TCR) gene segments, β-selection of cells expressing a functional TCRβ chain, positive selection of cells followed by CD4/CD8 lineage …
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