Serum markers for predicting significant necroinflammatory activity in patients with chronic hepatitis B

OBJECTIVES: The aim of this study was to determine the serum markers that predict significant inflammation in patients with chronic hepatitis B (CHB). DESIGN AND METHODS: Between October 2005 and June 2009, 384 subjects with CHB were enrolled. RESULTS: Multiple logistic regression analysis identified the ALT, hyaluronic acid (HA) and procollagen III N-terminal peptide (PIIINP) as independent predictors of significant inflammation (grade≥3). We constructed a formula for predicting significant inflammation. A significant inflammation (SI) score = 1.773 × ALT score + 1.599 × PIIINP score + 0.677 × HA score 1.962. The area under receiver operating characteristic curve of the SI score was 0.831. The sensitivity, specificity, positive predictive value and negative predictive value of the SI score were 79.5%, 70.8%, 76.8% and 74.3%, respectively. CONCLUSIONS: A simple scoring system including ALT, PIIINP and HA is an accurate non-invasive predictor of significant inflammatory activities in patients with CHB.

Author dc:creator

• 조, 효정

Contributors dc:contributor

• 정, 재연
• 대학원 의학과
• 107605

• apoptosis
• chronic hepatitis B
• cytokeratin-18
• significant inflammation
• 만성 B형 간염
• 염증 예측 모델
• hyaluronic acid
• procollagen III Nterminal peptide

Language dc:language

en

Identifier

http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000014771
000000014771

OAI identifier oai:identifier

oai:repository.ajou.ac.kr:201003/8653