Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"cytokeratin-18"”.
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The Significance of Cleaved Cytokeratin 18 in Pleural effusion
… 검사를 시행하였고 상피세포의 사멸을 평가하기 위하여 caspase-cleaved cytokeratin 18의 특이적 항원인 M30에 대한 항체를 이용하여 혈청 및 흉수에서 ELISA를 시행하였고 흉막 조직에서 면역조직화학염색을 시행하여 분석하였다. 결과 : 흉수 내 M30의 농도는 결핵 (2632.1 ± 1467.3 U/mL)에서 폐암 (956.5 ± 618.5 U/mL), 폐렴 (689.9 ± 413.6 U/mL), 심부전 (273.6 ± 144.5 U/mL; p < 0.01)보다 유의하게 높았다. 혈청 내 M30의 …
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Caspase-cleaved fragments of cytokeratin-18 as a marker of inflammatory activity in chronic hepatitis B virus infection
… chronic hepatitis B (CHB) virus infection. Serum cytokeratin (CK)-18 fragments (M30 antigen) are proposed as biomarkers of apoptosis. We investigated whether serum M30 levels might help to characterize the various phases of CHB and predict the state of significant inflammation in patients with …
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DEVELOPMENT OF IN VITRO NON-ALCOHOLIC STEATOHEPATITIS (NASH) MODEL FOR DRUG TESTING AND PATHOGENESIS STUDIES
… observed in in vivo settings. We recognized cytokeratin 18 fragment (M30) as a quantifiable biomarker for hepatocellular ballooning, which positively correlated with the level of steatosis and inflammation. ScRNA-seq was performed to find the ballooned hepatocyte cluster. An AMPK signalling …
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Changes in serum histologic surrogate markers and procollagen III N- terminal peptide as independent predictors of HBeAg loss in patients with chronic hepatitis B during entecavir therapy
… (PIIINP) and TIMP1, MMP2, hyaluronic acid and cytokeratin 18 fragment levels were significantly decreased and the haptoglobin level was significantly increased from baseline after entecavir treatment. Multivariate analysis identified PIIINP (P=0.028) and the initial virologic response (P=0.019) …
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EpitopeAnalysisofCytokeratin 18Protein binding withAutoantibodiesin SeraofPatientswith NonallergicAsthma.
… in sera of patients with nonallergic asthma and cytokeratin 18 (CK18) protein was identified as an autoantigen associated with nonallergic asthma. In this study, epitope of CK18 protein binding with autoantibodies in sera of patients with nonallergic asthma was analyzed. METHODS: We used sera of …
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Biomarker development for gastrointestinal and ovarian cancer: a proteomic approach
… index, lymphovascular invasion and tumour stage. Cytokeratin 18 (CK18) is an epithelial-specific cytokeratin that undergoes cleavage by caspases during apoptosis. Measurement of caspase-cleaved (CK18-NE) or total cytokeratin 18 (CK18) from epithelial-derived tumours could be a simple, non-invasive …
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Antitumor activity of antimalarials in human breast cancer cells
… The cells accumulated lipid droplets and the cytokeratin 18 cytoskeleton was reorganized. Hyperacetylated histone H4 appeared within 2 h of the addition of quinidine to the medium, and levels were maximal by 24 h. Quinidine treated MCF-7 cells showed elevated p21/WAF1, hypophosphorylation and …
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Development and characterization of recombinant human autoantibody using cDNA made from peripheral blood mononuclear cells of patients with bronchial asthma
… 분리 4 C. Polymerase chain reaction (PCR)을 이용한 cytokeratin 18 (CK-18) 단백질에 대한 인간 single-chain variable fragment (scFv) 항체 라이브러리의 구축 5 1. cDNA 합성과 중합효소 연쇄반응 (PCR) 5 2. scFv의 heavy chain과 light chain 합성 5 3. Overlapping PCR을 통한 인간재조합 scFv의 제작 5 4. Ligation 6 5. Library transformation 6 D. CK-18 …
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Serum markers for predicting significant necroinflammatory activity in patients with chronic hepatitis B
OBJECTIVES: The aim of this study was to determine the serum markers that predict significant inflammation in patients with chronic hepatitis B (CHB). DESIGN AND METHODS: Between October 2005 and June 2009, 384 subjects with CHB were enrolled. RESULTS: Multiple logistic regression analysis …