Prediction of Compensated Liver Cirrhosis by Ultrasonography and Routine Blood Tests in Patients with Chronic Viral Hepatitis

BACKGROUND: A liver biopsy is the standard method for the diagnosis of liver cirrhosis in patients with chronic hepatitis. Because the liver biopsy is an invasive method, non-invasive methods have been used to diagnose compensated liver cirrhosis in patients with chronic hepatitis. The current study was designed to evaluate ultrasonography and routine blood tests for diagnosing compensated liver cirrhosis in patients with chronic viral hepatitis. MATERIALS AND METHODS: Two hundred three patients with chronic viral hepatitis who underwent liver biopsy were included in this study and ultrasonography and routine blood tests were analyzed retrospectively. Ultrasonographic findings, such as surface nodularity, parenchyma echogenecity, and spleen size, were evaluated. The diagnostic accuracy of ultrasonography and routine blood tests were examined. RESULTS: Discriminant analysis with forward stepwise selection of the variables showed that liver surface nodularity, platelet count, and albumin level were independently associated with compensated liver cirrhosis (p<0.05). Cross-tabulation revealed that the following 4 variables had > 95% specificity: platelet count < 100,000 /uL; albumin level < 3.5 g/dL; INR > 1.3; and surface nodularity. If at least one of the 4 variables exists in a patient with chronic viral hepatitis, we can predict liver cirrhosis with 90% specificity and 61% sensitivity. CONCLUSIONS: These results suggest that 4 variables (platelet count < 100,000 /uL, albumin level < 3.5 g/dL, INR > 1.3, and surface nodularity) can be used to identify liver cirrhosis in patients with chronic viral hepatitis with high specificity.

Author dc:creator

• 이, 홍섭

Contributors dc:contributor

• 조, 성원
• 대학원 의학과
• 104871

• Liver Cirrhosis
• Diagnosis
• Ultrasonography
• Routine Blood Test
• Chronic Viral Hepatitis
• 만성바이러스성 간염
• 초음파
• 일반혈액검사
• 간경변증

Language dc:language

en

Identifier

http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000011202
000000011202

OAI identifier oai:identifier

oai:repository.ajou.ac.kr:201003/4317