The relationship between high-sensitive C-Reactive Protein and the obese type by fat distribution in middle-aged Koreans

BACKGROUND AND OBJECTIVE: Obesity and metabolic syndrome are closely correlated, previous studies showed that adipocytes release many inflammatory substances. HsCRP is an indicator of an independent risk factor in coronary heart disease. And hsCRP is regulated by inflammatory factors secreted from adipocytes. Study subjects were divided according to their body mass index, waist circumference. The aim of this study was to investigate the difference of hsCRP in different types of obese patients. METHOD: We analyzed the data of 7183 middle-aged Korean adults between the ages of 40 and 60(men 4,147, women 3,036) by using a cross-sectional approach. We divided study subjects into 4 different group; Normal Group(NG; normal waist and normal body mass index), Centrally Obese Group(OB1; Non-obese group with central obestiy), Obese Group without central obesity(OB2) and Obese Group with central obesity(OB3). We compared the difference of anthropometry, metabolic parameters, and hsCRP. RESULTS: Waist circumference(r＝0.230, p<.001) and body mass index(r＝0.222, p<.001) were positively correspond with high levels of hsCRP. Higher values of hsCRP were found in the OB3 compared to the NG. However, there was no difference between the OB1 and the OB2. Subjects who had central obesity or metabolic syndrome showed high hsCRP values. The hsCRP values were the highest in subjects who had central obesity with metabolic syndrome. But, the value of hsCRP was not significantly different in central obesity subjects with or without metabolic syndrome. A linear relationship between hsCRP levels and other inflammatory markers was found. Especially, there was a strong correlation between hsCRP and fibrinogen levels(r＝0.346, p<.001). CONCLUSION: The highest value of hsCRP was significantly showed in the obese group with central obesity. However, there were no differences found in the hsCRP levels between non-obese group with central obesity and obese group without central obesity.

Author dc:creator

• 주, 남석

Contributors dc:contributor

• 박, 샛별
• 대학원 의학과
• 104501

• 복부비만
• 대사증후군
• hsCRP
• central obesity
• metabolic syndrome

Language dc:language

ko

Identifier

http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000002123
000000002123

OAI identifier oai:identifier

oai:repository.ajou.ac.kr:201003/1653