The Comparison of Ondansetron or Dolasetron on the Prevention of Postoperative Nausea and Vomiting in Patients with intravenous Patient-Controlled Analgesia

PURPOSE: Postoperative nausea and vomiting (PONV) are common problem in patients undergoing breast surgery and incidence are increased in patients with intravenous patient-controlled analgesia(IV PCA). In this study, we evaluated the effect of ondansetron or dolasetron on the prevention of PONV in patients undergoing mastectomy with IV PCA. MATERIALS AND METHODS: 164 patients undergoing mastectomy were randomly divided into control group(Control, n=38), IV PCA only group (PCA group, n=42), IV PCA mixed with ondanseron group(PCA+O group n=42) and IV PCA mixed with dolasetron group(PCA+D group, n=42). The incidence of PONV, the need for rescue antiemetics, adverse events, nausea severity scores and vomiting severity score were analyzed for 0 to 1 hour and 1 to 24 hours postoperative peroids. RESULTS: During the first 24 hours postoperatively, the incidence of PONV were 45% for control group, 76.2% for PCA group(p<0.05 versus control group), 70.7% for PCA+ondansetron group and 66.7% for PCA+dolasetron group, respectively. The incidence need for rescue antiemetics were 21.1% for control group, 40.5% for PCA group(p<0.05 versus control group), 9.5% for PCA+ondansetron group(p<0.05 versus PCA group) and 4.8% for PCA+dolasetron group(p<0.05 versus PCA group), respectively. CONCLUSION: In patients undergoing mastectomy, IV PCA mixed with ondansetron or dolasetron were not effective for the reduction of the inceidence of PONV. However, the need for rescue antiemetics were significantly decreased.

Author dc:creator

• 김, 민석

Contributors dc:contributor

• 이, 숙영
• 대학원 의학과
• 200024192

• ondansetron
• dolasetron
• PONV
• 통증치료
• 정맥내

Language dc:language

ko

Identifier

http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000001893
000000001893

OAI identifier oai:identifier

oai:repository.ajou.ac.kr:201003/1625