Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"ondansetron"”.
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Prophylactic Ondansetron Administration to Attentuate Spinal Anesthesia-Induced Hypotension in Cesarean Section
… anesthesia providers on the prophylactic use of ondansetron to attenuate spinal anesthesia-induced hypotension (SAIH) in cesarean section. Knowledge acquisition and the intent to change practice will be measured to determine the impact. Background: Spinal anesthesia is a preferred technique in …
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The Comparison of Ondansetron or Dolasetron on the Prevention of Postoperative Nausea and Vomiting in Patients with intravenous Patient-Controlled Analgesia
… PCA). In this study, we evaluated the effect of ondansetron or dolasetron on the prevention of PONV in patients undergoing mastectomy with IV PCA. MATERIALS AND METHODS: 164 patients undergoing mastectomy were randomly divided into control group(Control, n=38), IV PCA only group (PCA group, …
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Studies into Amphetamine-Induced Unconditioned Behaviour in the Rat.
… a putative antipsychotic (a 5-HT3 antagonist, ondansetron) on open-field locomotor routes taken by rats following treatment with 3.5mg/kg amphetamine. Measures of stereotyped locomotion derived from image analysis were supported by a novel form of behavioural analysis based on multi-dimensional …
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Improvement of Gastroparesis Management By Addressing Challenges in Drug Metabolism: Studies with Metabolite Identification, Reaction Phenotyping and In Vitro Drug-Drug Interactions
… Domperidone in combination with pioglitazone and ondansetron was evaluated. Results showed that pioglitazone inhibited domperidone metabolism in-vitro. Our experiments did not predict a DDI for the domperidone - ondansetron combination. In summary, the ultimate goal of this thesis was to improve …
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5-HT3 Receptor Ligands and Their Effect on Psychomotor Stimulants
… similar to the 5-HT3 receptor antagonist, ondansetron. This effect could be occurring centrally; however peripheral effects can not be discounted. In combination with cocaine, MD-354 behaved similar to the 5-HT3 receptor agonist, SR 57227A, known to act both centrally and peripherally. This …
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Modified Delphi study to determine the components of a Medical Cache required for local or international medical deployment after a major incident or disaster
… on; while other pharmacological agents like Ondansetron and Thrombolytic agents did unsurprisingly not achieve consensus across any of the iterations. Conclusion: This study assisted in identifying the necessary medical equipment and pharmacological agents to be included in a medical cache, …
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Hot-melt extrusion: A versatile pharmaceutical technology
… sustained release (SR) tablets of ondansetron HCl dihydrate (OND). The in-vitro release study demonstrated sustained release for 24 h with 90% of drug release in formulations using stearic acid in combination with ethyl cellulose, whereas 100% drug release in 8 h for stearic …
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The Physiological Role of Serotonergic Transmission in Adult Rat Taste Buds
… bitter stimuli. On the other hand, injection of ondansetron, a 5-HT3 receptor antagonist, or saline, failed to produce any significant change in the chorda tympani responses to these lingually applied stimuli. These data provide solid evidence for a significant 5-HT1A-mediated role for serotonin …
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Interrogation of the neural mechanisms by which male and female rats assess aversive and mixed valence stimuli in learning and performing a task
… These data suggest that therapies such as ondansetron which target the AP are not effective in ANV because it is not a site activated during the ANV response. Further studies aimed at characterizing the cell types activated in the conditioned nausea response will help identify novel …