Transcatheter Arterial Embolization of Prostate in Hormone Induced Canine Prostate Hyperplasia

PURPOSE: Benign prostate hyperplasia (BPH) is the most common reason for surgical intervention among elderly men. Currently, main treatment modalities are medication and transurethral resection of the prostate (TURP) which is considered as the gold standard for the surgical management of symptomatic BPH. A number of minimally invasive techniques for treatment of BPH have increased significantly over the past 20 years. However, few new modalities have been presented so far, because of a limited results and some serious complications. There is a literature about transarterial prostate embolization is effective for the reduction in prostate volume and relief of urinary symptoms in a patient with BPH. The purposes of this study are to present the experiences of animal benign prostate hyperplasia model with combination therapy of hormones and to evaluate the efficacy and safety of transarterial prostate embolization for reduction of the volume in hormone induced canine prostate hyperplasia, prior to clinical application. MATERIALS AND METHODS: Nine castrated male beagle dogs were included. Prostate hyperplasia were induced by administration of dihydrotestosterone combined with β-estradiol in all dogs. In group A (n=4), the hormones were administered for 12 weeks. Two of them underwent transarterial embolization after hormone injections. Embolization was not performed in the remaining two. In groups B (n=5), the hormones were injected for 24 weeks. Three of them underwent embolization 12 weeks after initiation of the hormone treatment and embolization was not performed in the remaining 2. Embolization was performed using polyvinyl alcohol (PVA) particles. The volume of each prostate was measured 3 times by MR imaging in all dogs, before the hormone treatment, and 12 weeks and, 24 weeks after hormonal administration. The dogs were sacrificed and the prostates were harvested after 3rd MR imaging. The prostates and bladders were evaluated grossly as well as microscopically. RESULTS: The mean volume of the prostates increased by 157.23±112.11% in the nine dogs after 12 weeks of hormone administration. In group A (n=4), 3rd MRI at 24th week showed decreased prostate volume of 68.55±0.15% in non-embolized dogs and 81.02±6.60% in embolized dogs compared to 12th week. In group B (n=5), the dogs that underwent embolization (n=3) showed increased prostate volume of 40.21±14.99% and non-embolization group (n=2) revealed increased prostate volume of 71.13±1.52% between 2nd and 3rd MRI. There was no gross and microscopic change in bladders except focal hemorrhage in one specimen. Under the microscope, pathologic findings of the prostate in dogs that underwent embolization showed cystic change with regenerative epithelium, fibrosis and inflammatory cell infiltration, unlike the non-embolized dogs. CONCLUSION: Transcatheter arterial embolization is effective and safe to reduce the prostate volume without serious complications in hormone induced canine prostate hyperplasia.

Author dc:creator

• 전, 경식

Contributors dc:contributor

• 원, 제환
• 대학원 의학과
• 104515

• Prostate
• Hyperplasia
• Embolization
• 전립선 비대증
• 색전술

Language dc:language

en

Identifier

http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000006614
000000006614

OAI identifier oai:identifier

oai:repository.ajou.ac.kr:201003/1319