Association of Lamivudine-Resistant Mutational Patterns with the Antiviral Effect of Adefovir in Patients with Chronic Hepatitis B

"ABSTRACT ⅰ TABLE OF CONTENTS ⅱ LIST OF TABLES iii ABBREVIATION iv I. INTRODUCTION 1 II. MATERIALS AND METHODS 3 A. Patients 3 B. Blood tests 3 C. Detection of mutations by restriction fragment mass polymorphism (RFMP) Analysis 5 D. Sequencing analysis 6 E. Definition 6 F. Statistical analysis 7 III.RESULTS 8 A. Virologic and biochemical response to adefovir 8 B. Antiviral efficacy of Adefovir between the HBeAg-positive and -negative Groups 8 C. Baseline hepatitis B virus polymerase mutations 8 D. Effect of lamivudine-resistant mutational pattern on the virologic and biochemical response to adefovir 12 IV. DISCUSSION 15 V. CONCLUSION 18 REFERENCES 19 국문요약 24 "

Department dc:contributor.department

대학원 의학과

Year dc:date.issued

2009

Author dc:creator

• 차, 충근

Advisor dc:contributor.advisor

• 조, 성원

Contributors dc:contributor

• 대학원 의학과
• 199924555

Language dc:language.iso

en

Identifier

http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010011
000000010011

OAI record oai:identifier

http://repository.ajou.ac.kr/oai/request?verb=GetRecord&metadataPrefix=dim&identifier=oai%3Arepository.ajou.ac.kr%3A201003%2F1306