{"id":{"repo_id":"ajou","oai_identifier":"oai:repository.ajou.ac.kr:201003/1306"},"canonical_url":"https://search.dev.ndltd.org/etd/ajou/oai:repository.ajou.ac.kr:201003/1306","repository":{"repo_id":"ajou","name":"Ajou University","base_url":"http://repository.ajou.ac.kr/oai/request"},"display":{"title":"Association of Lamivudine-Resistant Mutational Patterns with the Antiviral Effect of Adefovir in Patients with Chronic Hepatitis B","abstract":"\"ABSTRACT ⅰ TABLE OF CONTENTS ⅱ LIST OF TABLES iii ABBREVIATION iv I. INTRODUCTION 1 II. MATERIALS AND METHODS 3 A. Patients 3 B. Blood tests 3 C. Detection of mutations by restriction fragment mass polymorphism (RFMP) Analysis 5 D. Sequencing analysis 6 E. Definition 6 F. Statistical analysis 7 III.RESULTS 8 A. Virologic and biochemical response to adefovir 8 B. Antiviral efficacy of Adefovir between the HBeAg-positive and -negative Groups 8 C. Baseline hepatitis B virus polymerase mutations 8 D. Effect of lamivudine-resistant mutational pattern on the virologic and biochemical response to adefovir 12 IV. DISCUSSION 15 V. CONCLUSION 18 REFERENCES 19 국문요약 24 \"","abstract_html":""ABSTRACT ⅰ TABLE OF CONTENTS ⅱ LIST OF TABLES iii ABBREVIATION iv I. INTRODUCTION 1 II. MATERIALS AND METHODS 3 A. Patients 3 B. Blood tests 3 C. Detection of mutations by restriction fragment mass polymorphism (RFMP) Analysis 5 D. Sequencing analysis 6 E. Definition 6 F. Statistical analysis 7 III.RESULTS 8 A. Virologic and biochemical response to adefovir 8 B. Antiviral efficacy of Adefovir between the HBeAg-positive and -negative Groups 8 C. Baseline hepatitis B virus polymerase mutations 8 D. Effect of lamivudine-resistant mutational pattern on the virologic and biochemical response to adefovir 12 IV. DISCUSSION 15 V. CONCLUSION 18 REFERENCES 19 국문요약 24 "","abstract_has_math":false,"creators":["차, 충근"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["조, 성원","대학원 의학과","199924555"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-01-26T06:48:53Z","date_published":"2011-01-26T06:48:53Z","updated_at":"2026-07-24T00:51:19Z","subjects":[],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010011","000000010011"],"render_values":[{"text":"http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010011","href":"http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010011","code":true},{"text":"000000010011","href":null,"code":true}]}]},"links":{"outbound_url":"http://repository.ajou.ac.kr/handle/201003/1306","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["조, 성원","대학원 의학과","199924555","차, 충근"]},{"key":"dc:creator","label":"Author","values":["차, 충근"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-01-26T06:48:53Z","2009"]},{"key":"dc:type","label":"Dc Type","values":["Thesis","Theses"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://repository.ajou.ac.kr/handle/201003/1306","http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010011","000000010011"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["\"ABSTRACT ⅰ TABLE OF CONTENTS ⅱ LIST OF TABLES iii ABBREVIATION iv I. 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