Significance of Salivary Gland Radioiodine Retention on Post-ablation 131I Scintigraphy as a Predictor of Salivary Gland Dysfunction in Patients with Differentiated Thyroid Carcinoma

PURPOSE: We investigated whether 131Iwhole-body scintigraphy could predict functional changes in salivary glands after radioiodine therapy. METHODS: We evaluated 90 patients who received initial high-dose (≥3.7 GBq) radioiodine therapy after totalthyroidectomy.Allpatients underwent diagnostic (DWS) and post-ablation (TWS) 131I whole-body scintigraphy. Visual assessment of salivary radioiodine retention on DWS and TWS was used to divide the patients into two types of groups : aDWS+orDWS-group and aTWS+orTWS-group. Salivary gland scintigraphy was also performed before DWS and at the first follow-up visit. Peak up take and % was hout were calculated in ROI so feach gland. Functional changes (Δup take or Δwas hout) of salivary glands after radioiodine therapy were compared between the two groups. RESULTS: Both peak uptake and the %was hout of the parotid glands were significantly lower after radioiodine therapy (allp values <0.001),whereas only the %wash out were significantly reduced in the submandibular glands (all p values<0.05). For the parotid glands, the TWS+ groups howed larger Δuptake and Δwashout after radioiodine therapy than did the TWS- group (all p values <0.01). In contrast, the Δuptake and Δwashout of the submandibular glands did not significantly differ between the TWS+ and TWS- groups (allp values >0.05). Likewise,no differences in Δuptake or Δwashout were apparent between the DWS+ and DWS-groups in either the parotid or submandibular glands (allpvalues>0.05). CONCLUSION: Salivary gland radioiodine retention on post-ablation 131I scintigraphy is a good predictor of functional impairment of the parotidglands after high-dose radioiodine therapy.

Author dc:creator

• 조, 경숙

Contributors dc:contributor

• 윤, 준기
• 대학원 의학과
• 108051

• Radioiodine therapy
• Salivary gland dysfunction
• Differentiated thyroid cancer
• 131Iscintigraphy
• Salivarygl and scintigraphy
• 방사성 요오드 치료
• 타액선 기능 변화
• 분화성 갑상선암
• 전신 요오드 스캔
• 타액선 섬광조영술

Language dc:language

en

Identifier

http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000017394
000000017394

OAI identifier oai:identifier

oai:repository.ajou.ac.kr:201003/10928