{"id":{"repo_id":"ajou","oai_identifier":"oai:repository.ajou.ac.kr:201003/10928"},"canonical_url":"https://search.dev.ndltd.org/etd/ajou/oai:repository.ajou.ac.kr:201003/10928","repository":{"repo_id":"ajou","name":"Ajou University","base_url":"http://repository.ajou.ac.kr/oai/request"},"display":{"title":"Significance of Salivary Gland Radioiodine Retention on Post-ablation 131I Scintigraphy as a Predictor of Salivary Gland Dysfunction in Patients with Differentiated Thyroid Carcinoma","abstract":"PURPOSE: We investigated whether 131Iwhole-body scintigraphy could predict functional changes in salivary glands after radioiodine therapy. METHODS: We evaluated 90 patients who received initial high-dose (≥3.7 GBq) radioiodine therapy after totalthyroidectomy.Allpatients underwent diagnostic (DWS) and post-ablation (TWS) 131I whole-body scintigraphy. Visual assessment of salivary radioiodine retention on DWS and TWS was used to divide the patients into two types of groups : aDWS+orDWS-group and aTWS+orTWS-group. Salivary gland scintigraphy was also performed before DWS and at the first follow-up visit. Peak up take and % was hout were calculated in ROI so feach gland. Functional changes (Δup take or Δwas hout) of salivary glands after radioiodine therapy were compared between the two groups. RESULTS: Both peak uptake and the %was hout of the parotid glands were significantly lower after radioiodine therapy (allp values <0.001),whereas only the %wash out were significantly reduced in the submandibular glands (all p values<0.05). For the parotid glands, the TWS+ groups howed larger Δuptake and Δwashout after radioiodine therapy than did the TWS- group (all p values <0.01). In contrast, the Δuptake and Δwashout of the submandibular glands did not significantly differ between the TWS+ and TWS- groups (allp values >0.05). Likewise,no differences in Δuptake or Δwashout were apparent between the DWS+ and DWS-groups in either the parotid or submandibular glands (allpvalues>0.05). CONCLUSION: Salivary gland radioiodine retention on post-ablation 131I scintigraphy is a good predictor of functional impairment of the parotidglands after high-dose radioiodine therapy.","abstract_html":"PURPOSE: We investigated whether 131Iwhole-body scintigraphy could predict functional changes in salivary glands after radioiodine therapy. METHODS: We evaluated 90 patients who received initial high-dose (≥3.7 GBq) radioiodine therapy after totalthyroidectomy.Allpatients underwent diagnostic (DWS) and post-ablation (TWS) 131I whole-body scintigraphy. Visual assessment of salivary radioiodine retention on DWS and TWS was used to divide the patients into two types of groups : aDWS+orDWS-group and aTWS+orTWS-group. Salivary gland scintigraphy was also performed before DWS and at the first follow-up visit. Peak up take and % was hout were calculated in ROI so feach gland. Functional changes (Δup take or Δwas hout) of salivary glands after radioiodine therapy were compared between the two groups. RESULTS: Both peak uptake and the %was hout of the parotid glands were significantly lower after radioiodine therapy (allp values &lt;0.001),whereas only the %wash out were significantly reduced in the submandibular glands (all p values&lt;0.05). For the parotid glands, the TWS+ groups howed larger Δuptake and Δwashout after radioiodine therapy than did the TWS- group (all p values &lt;0.01). In contrast, the Δuptake and Δwashout of the submandibular glands did not significantly differ between the TWS+ and TWS- groups (allp values &gt;0.05). Likewise,no differences in Δuptake or Δwashout were apparent between the DWS+ and DWS-groups in either the parotid or submandibular glands (allpvalues&gt;0.05). CONCLUSION: Salivary gland radioiodine retention on post-ablation 131I scintigraphy is a good predictor of functional impairment of the parotidglands after high-dose radioiodine therapy.","abstract_has_math":false,"creators":["조, 경숙"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["윤, 준기","대학원 의학과","108051"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-11-14T01:53:33Z","date_published":"2014-11-14T01:53:33Z","updated_at":"2026-07-24T00:51:47Z","subjects":["Radioiodine therapy","Salivary gland dysfunction","Differentiated thyroid cancer","131Iscintigraphy","Salivarygl and scintigraphy","방사성 요오드 치료","타액선 기능 변화","분화성 갑상선암","전신 요오드 스캔","타액선 섬광조영술"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000017394","000000017394"],"render_values":[{"text":"http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000017394","href":"http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000017394","code":true},{"text":"000000017394","href":null,"code":true}]}]},"links":{"outbound_url":"http://repository.ajou.ac.kr/handle/201003/10928","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["윤, 준기","대학원 의학과","108051","조, 경숙"]},{"key":"dc:creator","label":"Author","values":["조, 경숙"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2014-11-14T01:53:33Z","2014"]},{"key":"dc:type","label":"Dc Type","values":["Thesis","Theses"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Radioiodine therapy","Salivary gland dysfunction","Differentiated thyroid cancer","131Iscintigraphy","Salivarygl and scintigraphy","방사성 요오드 치료","타액선 기능 변화","분화성 갑상선암","전신 요오드 스캔","타액선 섬광조영술"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://repository.ajou.ac.kr/handle/201003/10928","http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000017394","000000017394"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["PURPOSE: We investigated whether 131Iwhole-body scintigraphy could predict functional changes in salivary glands after radioiodine therapy. METHODS: We evaluated 90 patients who received initial high-dose (≥3.7 GBq) radioiodine therapy after totalthyroidectomy.Allpatients underwent diagnostic (DWS) and post-ablation (TWS) 131I whole-body scintigraphy. Visual assessment of salivary radioiodine retention on DWS and TWS was used to divide the patients into two types of groups : aDWS+orDWS-group and aTWS+orTWS-group. Salivary gland scintigraphy was also performed before DWS and at the first follow-up visit. Peak up take and % was hout were calculated in ROI so feach gland. Functional changes (Δup take or Δwas hout) of salivary glands after radioiodine therapy were compared between the two groups. RESULTS: Both peak uptake and the %was hout of the parotid glands were significantly lower after radioiodine therapy (allp values <0.001),whereas only the %wash out were significantly reduced in the submandibular glands (all p values<0.05). For the parotid glands, the TWS+ groups howed larger Δuptake and Δwashout after radioiodine therapy than did the TWS- group (all p values <0.01). In contrast, the Δuptake and Δwashout of the submandibular glands did not significantly differ between the TWS+ and TWS- groups (allp values >0.05). Likewise,no differences in Δuptake or Δwashout were apparent between the DWS+ and DWS-groups in either the parotid or submandibular glands (allpvalues>0.05). CONCLUSION: Salivary gland radioiodine retention on post-ablation 131I scintigraphy is a good predictor of functional impairment of the parotidglands after high-dose radioiodine therapy.","분화성 갑상선암으로 방사성 요오드 치료를 받은 환자에서 전신 요오드 스캔을 통한 타액선 기능 변화 예측이 가능한지 알아보고자 하였다.2010년 6월부터 2011년 10월까지 분화성 갑상선암으로 갑상선 전절제술 후 첫번째 고용량 방사성 요오드 치료를 받은 환자 중,진단 및 치료 후 전신 요오드 스캔과 치료 전후 두 차례의 타액선 섬광조영술 모두를 시행한 90명의 환자를 대상으로 하였다. 이 환자들의 진단 및 치료 후 전신 요오드 스캔 상 관찰되는 타액선 부위의 섭취증가 유,무에 따라 각각 두 가지 그룹으로 분류하였으며, 치료 전후의 타액선 섬광조영술을 통하여 이하선 및 악하선의 섭취율 및 배설율의 변화를 알아보았다. 전신 요오드 스캔에서 관찰되는 타액선 부위의 섭취증가와 방사성 요오드 치료 후 타액선 기능 변화 사이의 연관성에 대해 분석한 결과,치료 후 전신 요오드 스캔에서 이하선 부위에 섭취증가를 보이는 환자군의 경우 섭취증가를 보이지 않는 환자군에 비해 방사성 요오드 치료 후 이하선의 섭취율 및 배설율이 유의하게 감소한 반면,악하선 부위의 섭취증가 유무는 타액선 기능변화와 별다른 관계가 없었다. 이와 마찬가지로,진단 전신 요오드 스캔에서 관찰되는 이하선 및 악하선 부위의 섭취증가는 치료 후 타액선 기능 변화와 연관성이 없었다. 따라서 고용량 방사성 요오드 치료 후 전신 요오드 스캔에서 이하선 부위에 섭취증가를 보이는 환자의 경우 이하선의 기능저하를 예측할 수 있으며 이를 통해 타액선 기능 변화에 대한 적절한 예방 및 치료에 도움이 될 것으로 사료된다.","ABSTRACT ⅰ TABLE OF CONTENTS ⅲ LIST OF FIGURES ⅳ LIST OF TABLES ⅴ Ⅰ. Introduction 1 Ⅱ. Materials and Methods 4 A. Subjects 4 B. Radioiodine Treatment Protocol 5 C. Acquisition and Image Analysis of Salivary Gland Scintigraphy 6 D. Acquisition and Image Analysis of 131I Whole-Body Scintigraphy 8 E. Statistical Analysis 9 Ⅲ.Results 10 A. Characteristics of Patients 10 B. Salivary Gland Function 11 C. Radioiodine Retention on131I Whole-Body Scintigraphy 12 D. Relation between Radioiodine Retention and Salivary Gland Function 13 Ⅳ. Discussion 16 V. Conclusion 22 References 23 국문요약 26","Master"]},{"key":"dc:title","label":"Title","values":["Significance of Salivary Gland Radioiodine Retention on Post-ablation 131I Scintigraphy as a Predictor of Salivary Gland Dysfunction in Patients with Differentiated Thyroid Carcinoma","방사성 요오드 치료를 받은 분화성 갑상선암 환자의 전신 요오드 스캔 상 관찰되는 침샘 섭취와 타액선 기능 변화의 연관성"]}]}],"canonical_facts":{"dc:contributor":["윤, 준기","대학원 의학과","108051","조, 경숙"],"dc:creator":["조, 경숙"],"dc:date":["2014-11-14T01:53:33Z","2014"],"dc:description":["PURPOSE: We investigated whether 131Iwhole-body scintigraphy could predict functional changes in salivary glands after radioiodine therapy. METHODS: We evaluated 90 patients who received initial high-dose (≥3.7 GBq) radioiodine therapy after totalthyroidectomy.Allpatients underwent diagnostic (DWS) and post-ablation (TWS) 131I whole-body scintigraphy. Visual assessment of salivary radioiodine retention on DWS and TWS was used to divide the patients into two types of groups : aDWS+orDWS-group and aTWS+orTWS-group. Salivary gland scintigraphy was also performed before DWS and at the first follow-up visit. Peak up take and % was hout were calculated in ROI so feach gland. Functional changes (Δup take or Δwas hout) of salivary glands after radioiodine therapy were compared between the two groups. RESULTS: Both peak uptake and the %was hout of the parotid glands were significantly lower after radioiodine therapy (allp values <0.001),whereas only the %wash out were significantly reduced in the submandibular glands (all p values<0.05). For the parotid glands, the TWS+ groups howed larger Δuptake and Δwashout after radioiodine therapy than did the TWS- group (all p values <0.01). In contrast, the Δuptake and Δwashout of the submandibular glands did not significantly differ between the TWS+ and TWS- groups (allp values >0.05). Likewise,no differences in Δuptake or Δwashout were apparent between the DWS+ and DWS-groups in either the parotid or submandibular glands (allpvalues>0.05). CONCLUSION: Salivary gland radioiodine retention on post-ablation 131I scintigraphy is a good predictor of functional impairment of the parotidglands after high-dose radioiodine therapy.","분화성 갑상선암으로 방사성 요오드 치료를 받은 환자에서 전신 요오드 스캔을 통한 타액선 기능 변화 예측이 가능한지 알아보고자 하였다.2010년 6월부터 2011년 10월까지 분화성 갑상선암으로 갑상선 전절제술 후 첫번째 고용량 방사성 요오드 치료를 받은 환자 중,진단 및 치료 후 전신 요오드 스캔과 치료 전후 두 차례의 타액선 섬광조영술 모두를 시행한 90명의 환자를 대상으로 하였다. 이 환자들의 진단 및 치료 후 전신 요오드 스캔 상 관찰되는 타액선 부위의 섭취증가 유,무에 따라 각각 두 가지 그룹으로 분류하였으며, 치료 전후의 타액선 섬광조영술을 통하여 이하선 및 악하선의 섭취율 및 배설율의 변화를 알아보았다. 전신 요오드 스캔에서 관찰되는 타액선 부위의 섭취증가와 방사성 요오드 치료 후 타액선 기능 변화 사이의 연관성에 대해 분석한 결과,치료 후 전신 요오드 스캔에서 이하선 부위에 섭취증가를 보이는 환자군의 경우 섭취증가를 보이지 않는 환자군에 비해 방사성 요오드 치료 후 이하선의 섭취율 및 배설율이 유의하게 감소한 반면,악하선 부위의 섭취증가 유무는 타액선 기능변화와 별다른 관계가 없었다. 이와 마찬가지로,진단 전신 요오드 스캔에서 관찰되는 이하선 및 악하선 부위의 섭취증가는 치료 후 타액선 기능 변화와 연관성이 없었다. 따라서 고용량 방사성 요오드 치료 후 전신 요오드 스캔에서 이하선 부위에 섭취증가를 보이는 환자의 경우 이하선의 기능저하를 예측할 수 있으며 이를 통해 타액선 기능 변화에 대한 적절한 예방 및 치료에 도움이 될 것으로 사료된다.","ABSTRACT ⅰ TABLE OF CONTENTS ⅲ LIST OF FIGURES ⅳ LIST OF TABLES ⅴ Ⅰ. Introduction 1 Ⅱ. Materials and Methods 4 A. Subjects 4 B. Radioiodine Treatment Protocol 5 C. Acquisition and Image Analysis of Salivary Gland Scintigraphy 6 D. Acquisition and Image Analysis of 131I Whole-Body Scintigraphy 8 E. Statistical Analysis 9 Ⅲ.Results 10 A. Characteristics of Patients 10 B. Salivary Gland Function 11 C. Radioiodine Retention on131I Whole-Body Scintigraphy 12 D. Relation between Radioiodine Retention and Salivary Gland Function 13 Ⅳ. Discussion 16 V. Conclusion 22 References 23 국문요약 26","Master"],"dc:identifier":["http://repository.ajou.ac.kr/handle/201003/10928","http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000017394","000000017394"],"dc:language":["en"],"dc:subject":["Radioiodine therapy","Salivary gland dysfunction","Differentiated thyroid cancer","131Iscintigraphy","Salivarygl and scintigraphy","방사성 요오드 치료","타액선 기능 변화","분화성 갑상선암","전신 요오드 스캔","타액선 섬광조영술"],"dc:title":["Significance of Salivary Gland Radioiodine Retention on Post-ablation 131I Scintigraphy as a Predictor of Salivary Gland Dysfunction in Patients with Differentiated Thyroid Carcinoma","방사성 요오드 치료를 받은 분화성 갑상선암 환자의 전신 요오드 스캔 상 관찰되는 침샘 섭취와 타액선 기능 변화의 연관성"],"dc:type":["Thesis","Theses"]},"updated_at":"2026-07-24T00:51:47Z"}