Abstract
dc:description.abstractA 3-step process for the conversion of C-4 disubstituted ceph-2-ems into ceph-3-ems, where the original C-4 carboxyl group is replaced by a substituted ethyl group, is described. A range of novel compounds (A-D) are produced. Ester (B) is converted into carboxylic acid (E).<br/><br/>The regiospecificity of alkylation reactions of ceph-3-em sulphides, α- sulphoxides and β-sulphoxides is investigated for a variety of bases and electrophiles. C-4 disubstituted ceph-2-ems thus obtained are converted into the novel β-lactams (F & G).<br/><br/>A novel class of ceph-3-ems bearing C-2 exocyclic double bond systems containing two heteroatoms is described (H-J). Ester (H) is converted into acid (L).<br/><br/>None of the new β-lactams obtained exhibited any significant biological activity.
Degree
thesis:*- Name dc:type.qualificationname
- PhD
- Level dc:type.qualificationlevel
- Doctoral Thesis
- Year dc:date.issued
- 1989
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Ringan, Neil
Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- oai:rke.abertay.ac.uk:studenttheses/50afaa9f-5a32-4d2e-862a-dd4415ceadaf
- OAI identifier oai:identifier
- oai:rke.abertay.ac.uk:studenttheses/50afaa9f-5a32-4d2e-862a-dd4415ceadaf