{"id":{"repo_id":"abertay","oai_identifier":"oai:rke.abertay.ac.uk:studenttheses/50afaa9f-5a32-4d2e-862a-dd4415ceadaf"},"canonical_url":"https://search.dev.ndltd.org/etd/abertay/oai:rke.abertay.ac.uk:studenttheses/50afaa9f-5a32-4d2e-862a-dd4415ceadaf","repository":{"repo_id":"abertay","name":"Abertay University","base_url":"https://rke.abertay.ac.uk/ws/oai"},"display":{"title":"New reactions of ceph-3-ems","abstract":"A 3-step process for the conversion of C-4 disubstituted ceph-2-ems into ceph-3-ems, where the original C-4 carboxyl group is replaced by a substituted ethyl group, is described. A range of novel compounds (A-D) are produced. Ester (B) is converted into carboxylic acid (E).<br/><br/>The regiospecificity of alkylation reactions of ceph-3-em sulphides, α- sulphoxides and β-sulphoxides is investigated for a variety of bases and electrophiles. C-4 disubstituted ceph-2-ems thus obtained are converted into the novel β-lactams (F &amp; G).<br/><br/>A novel class of ceph-3-ems bearing C-2 exocyclic double bond systems containing two heteroatoms is described (H-J). Ester (H) is converted into acid (L).<br/><br/>None of the new β-lactams obtained exhibited any significant biological activity.","abstract_html":"A 3-step process for the conversion of C-4 disubstituted ceph-2-ems into ceph-3-ems, where the original C-4 carboxyl group is replaced by a substituted ethyl group, is described. A range of novel compounds (A-D) are produced. Ester (B) is converted into carboxylic acid (E).&lt;br/&gt;&lt;br/&gt;The regiospecificity of alkylation reactions of ceph-3-em sulphides, α- sulphoxides and β-sulphoxides is investigated for a variety of bases and electrophiles. C-4 disubstituted ceph-2-ems thus obtained are converted into the novel β-lactams (F &amp;amp; G).&lt;br/&gt;&lt;br/&gt;A novel class of ceph-3-ems bearing C-2 exocyclic double bond systems containing two heteroatoms is described (H-J). Ester (H) is converted into acid (L).&lt;br/&gt;&lt;br/&gt;None of the new β-lactams obtained exhibited any significant biological activity.","abstract_has_math":false,"creators":["Ringan, Neil"],"institution":null,"degree_name":"PhD","degree_level":"Doctoral Thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1989,"date_issued":"1989-11","date_published":"1989-11","updated_at":"2026-07-24T00:50:16Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:rke.abertay.ac.uk:studenttheses/50afaa9f-5a32-4d2e-862a-dd4415ceadaf"],"render_values":[{"text":"oai:rke.abertay.ac.uk:studenttheses/50afaa9f-5a32-4d2e-862a-dd4415ceadaf","href":null,"code":true}]}]},"links":{"outbound_url":"https://rke.abertay.ac.uk/en/studentTheses/50afaa9f-5a32-4d2e-862a-dd4415ceadaf","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Ringan, Neil"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1989-11"]},{"key":"dc:date.issued","label":"Date","values":["1989-11"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Dundee Institute of Technology"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://rke.abertay.ac.uk/en/studentTheses/50afaa9f-5a32-4d2e-862a-dd4415ceadaf"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["PhD"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:rke.abertay.ac.uk:studenttheses/50afaa9f-5a32-4d2e-862a-dd4415ceadaf","https://rke.abertay.ac.uk/en/studentTheses/50afaa9f-5a32-4d2e-862a-dd4415ceadaf"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://rke.abertay.ac.uk/files/15666121/Ringan_1989_New_reactions_of_ceph_3_ems_PhD.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["A 3-step process for the conversion of C-4 disubstituted ceph-2-ems into ceph-3-ems, where the original C-4 carboxyl group is replaced by a substituted ethyl group, is described. A range of novel compounds (A-D) are produced. Ester (B) is converted into carboxylic acid (E).<br/><br/>The regiospecificity of alkylation reactions of ceph-3-em sulphides, α- sulphoxides and β-sulphoxides is investigated for a variety of bases and electrophiles. C-4 disubstituted ceph-2-ems thus obtained are converted into the novel β-lactams (F &amp; G).<br/><br/>A novel class of ceph-3-ems bearing C-2 exocyclic double bond systems containing two heteroatoms is described (H-J). Ester (H) is converted into acid (L).<br/><br/>None of the new β-lactams obtained exhibited any significant biological activity."]},{"key":"dc:title","label":"Title","values":["New reactions of ceph-3-ems"]}]}],"canonical_facts":{"dc:creator":["Ringan, Neil"],"dc:date":["1989-11"],"dc:date.issued":["1989-11"],"dc:description.abstract":["A 3-step process for the conversion of C-4 disubstituted ceph-2-ems into ceph-3-ems, where the original C-4 carboxyl group is replaced by a substituted ethyl group, is described. A range of novel compounds (A-D) are produced. Ester (B) is converted into carboxylic acid (E).<br/><br/>The regiospecificity of alkylation reactions of ceph-3-em sulphides, α- sulphoxides and β-sulphoxides is investigated for a variety of bases and electrophiles. C-4 disubstituted ceph-2-ems thus obtained are converted into the novel β-lactams (F &amp; G).<br/><br/>A novel class of ceph-3-ems bearing C-2 exocyclic double bond systems containing two heteroatoms is described (H-J). Ester (H) is converted into acid (L).<br/><br/>None of the new β-lactams obtained exhibited any significant biological activity."],"dc:identifier":["oai:rke.abertay.ac.uk:studenttheses/50afaa9f-5a32-4d2e-862a-dd4415ceadaf","https://rke.abertay.ac.uk/en/studentTheses/50afaa9f-5a32-4d2e-862a-dd4415ceadaf"],"dc:identifier.uri":["https://rke.abertay.ac.uk/files/15666121/Ringan_1989_New_reactions_of_ceph_3_ems_PhD.pdf"],"dc:language":["eng"],"dc:publisher.department":["Dundee Institute of Technology"],"dc:relation.isreferencedby":["https://rke.abertay.ac.uk/en/studentTheses/50afaa9f-5a32-4d2e-862a-dd4415ceadaf"],"dc:title":["New reactions of ceph-3-ems"],"dc:type":["Thesis"],"dc:type.qualificationlevel":["Doctoral Thesis"],"dc:type.qualificationname":["PhD"]},"updated_at":"2026-07-24T00:50:16Z"}