Skelettmuskelproteinumsatz nach kontrakturlösenden Operationen bei Patienten mit Duchenne-Muskeldystrophie

Previous studies have shown a decreased progression of the course in Duchenne muscular dystrophy (DMD) patients treated by lower limb surgery in early childhood. The use of 3-methylhistidine (3-MH) excretion and 3-MH/creatinine excretion ratio as an appropriate indicator for the myofibrillar protein catabolic rate (MPCR) in muscle disorders is discussed controversially. To explore this issue we studied the renal excretion of 3-MH over a period up to 24 months (on average 20.5 SD 2.1) after operation in 16 consecutive DMD patients with an average age at operation of 8.75 (SD 2.34) years to evaluate the myofibrillar protein catabolic rate. No significant change of the MPCR could be found in our population over the follow-up period. However, the formula for the calculation of the MPCR contains quantities which are not precisely known in DMD or assumed to be constant over the progressive course of DMD. Summarising MPCR cannot be recommended for the assessment of therapeutic efficacy in DMD.

Grantor dc:publisher

Publikationsserver der RWTH Aachen University

Year dc:date

2001

Author dc:creator

• Krüger, Rolf Peter

Contributors dc:contributor

• Forst, Raimund

• info:eu-repo/classification/ddc/610
• Medizin

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

ger

Identifier

https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-118823%22

OAI record oai:identifier

https://publications.rwth-aachen.de/oai2d?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Apublications.rwth-aachen.de%3A56736