Untersuchung des intrazellulären Kontrastmittels MnCl2 zur Darstellung des akuten Myokardinfarktes

PURPOSE: To determine wether normal myocardium can be distinguished from infarction at enhanced MR imaging with a dose of 25 µmol/kg MnCl2. MATERIALS AND METHODS: After 45 minutes coronary arterial occlusion and 2-hour reperfusion, a group of 7 pigs was injected with 25 µmol of the intracellular contrast media MnCl2 per kilogram of body weight. Look-Locker images were acquired to measure longitudinal relaxation times (T1) in normal myocardium, reperfused infarction, chamber blood and autochthonous back musculature. T1 values were measured before the administration of MnCl2 and at 15-minute intervals during 4 hours afterward by using a 1,5-T unit. RESULTS: There was no noticeable washout of the contrast media in normal myocardium over the time. The contrast agent cleared from the blood pool and infarcted area rapidly. After administration of MnCl2, T1 values of the autochthonous back musculature did not not significantly differ during 4 hours. CONCLUSION: MnCl2 allows differentiation between normal and acutely infarcted myocardium. This intracellular contrast media has characteristics similar to those of widely used thallium and may be useful in the assessment of myocardial viability at MR imaging

Grantor dc:publisher

Publikationsserver der RWTH Aachen University

Year dc:date

2007

Author dc:creator

• Bellen, Kathrin

Contributors dc:contributor

• Günther, Rolf W.

• info:eu-repo/classification/ddc/610
• Kontrastmittel
• Medizin
• Myokardinfarkt
• MRT
• Myocardium
• Infarction
• Contrast media
• Magnetic resonance (MR)

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

ger

Identifier

https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-114220%22

OAI record oai:identifier

https://publications.rwth-aachen.de/oai2d?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Apublications.rwth-aachen.de%3A51974