Diagnostischer Wert der 64-Zeilen-Mehrschichtspiral-Computertomographie des Herzens bei symptomatischen Patienten

AIMS: Cardiac multi-detector row computed tomography (MDCT) angiography has shown high levels of sensitivity and especially negative predictive value regarding the diagnosis of coronary artery disease (CAD) especially in patients with a low pre-test probability. This study was designed to determine the value of a 64-slice-MDCT scanner in comparison to invasive coronary angiography for the detection of CAD in a population of symptomatic patients.MATERIAL AND METHODS: 50 patients with suspected CAD underwent conventional coronary angiography and ECG-gated cardiac 64-slice-MDCT angiography. Blinded patient- and segment-based analysis was performed for the detection of stenoses '70% of the vessel lumen. Sensitivity, specificity, positive and negative predictive values and inter-rater agreement were calculated.RESULTS: 94.3% of all coronary segments were assessable by MDCT angiography. Patient-based (segment-based) analysis revealed a sensitivity of 97.7% (86.6%), specificity of 50.0% (95.7%) positive predictive value of 93.5% (76.6%) and negative predictive value of 75.0% (97.8%) considering the invasive coronary angiography as the diagnostic gold standard for CAD.CONCLUSION: In this patient collective 64-slice-MDCT coronary angiography is not yet ready to replace invasive coronary angiography in a population of symptomatic patients. However it can be expected, that by technical progression of multi-detector row computed tomography, MDCT will become a significant, additional tool in risk evaluation of CAD.

Grantor dc:publisher

Publikationsserver der RWTH Aachen University

Year dc:date

2010

Author dc:creator

• Au, Michael Roland

Contributors dc:contributor

• Mahnken, Andreas H.

• info:eu-repo/classification/ddc/610
• Spiral-CT
• Computertomographie
• Angiographie
• Framingham-Studie
• Herzkrankheit
• Koronare Herzkrankheit
• Medizin
• CT
• angiography
• coronary artery disease
• heart
• computed tomography

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

ger

Identifier

https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-114056%22

OAI record oai:identifier

https://publications.rwth-aachen.de/oai2d?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Apublications.rwth-aachen.de%3A51804