{"id":{"repo_id":"aachen","oai_identifier":"oai:publications.rwth-aachen.de:51804"},"canonical_url":"https://search.dev.ndltd.org/etd/aachen/oai:publications.rwth-aachen.de:51804","repository":{"repo_id":"aachen","name":"RWTH Aachen University","base_url":"https://publications.rwth-aachen.de/oai2d"},"display":{"title":"Diagnostischer Wert der 64-Zeilen-Mehrschichtspiral-Computertomographie des Herzens bei symptomatischen Patienten","abstract":"AIMS: Cardiac multi-detector row computed tomography (MDCT) angiography has shown high levels of sensitivity and especially negative predictive value regarding the diagnosis of coronary artery disease (CAD) especially in patients with a low pre-test probability. This study was designed to determine the value of a 64-slice-MDCT scanner in comparison to invasive coronary angiography for the detection of CAD in a population of symptomatic patients.MATERIAL AND METHODS: 50 patients with suspected CAD underwent conventional coronary angiography and ECG-gated cardiac 64-slice-MDCT angiography. Blinded patient- and segment-based analysis was performed for the detection of stenoses '70% of the vessel lumen. Sensitivity, specificity, positive and negative predictive values and inter-rater agreement were calculated.RESULTS: 94.3% of all coronary segments were assessable by MDCT angiography. Patient-based (segment-based) analysis revealed a sensitivity of 97.7% (86.6%), specificity of 50.0% (95.7%) positive predictive value of 93.5% (76.6%) and negative predictive value of 75.0% (97.8%) considering the invasive coronary angiography as the diagnostic gold standard for CAD.CONCLUSION: In this patient collective 64-slice-MDCT coronary angiography is not yet ready to replace invasive coronary angiography in a population of symptomatic patients. However it can be expected, that by technical progression of multi-detector row computed tomography, MDCT will become a significant, additional tool in risk evaluation of CAD.","abstract_html":"AIMS: Cardiac multi-detector row computed tomography (MDCT) angiography has shown high levels of sensitivity and especially negative predictive value regarding the diagnosis of coronary artery disease (CAD) especially in patients with a low pre-test probability. This study was designed to determine the value of a 64-slice-MDCT scanner in comparison to invasive coronary angiography for the detection of CAD in a population of symptomatic patients.MATERIAL AND METHODS: 50 patients with suspected CAD underwent conventional coronary angiography and ECG-gated cardiac 64-slice-MDCT angiography. Blinded patient- and segment-based analysis was performed for the detection of stenoses '70% of the vessel lumen. Sensitivity, specificity, positive and negative predictive values and inter-rater agreement were calculated.RESULTS: 94.3% of all coronary segments were assessable by MDCT angiography. Patient-based (segment-based) analysis revealed a sensitivity of 97.7% (86.6%), specificity of 50.0% (95.7%) positive predictive value of 93.5% (76.6%) and negative predictive value of 75.0% (97.8%) considering the invasive coronary angiography as the diagnostic gold standard for CAD.CONCLUSION: In this patient collective 64-slice-MDCT coronary angiography is not yet ready to replace invasive coronary angiography in a population of symptomatic patients. However it can be expected, that by technical progression of multi-detector row computed tomography, MDCT will become a significant, additional tool in risk evaluation of CAD.","abstract_has_math":false,"creators":["Au, Michael Roland"],"institution":"Publikationsserver der RWTH Aachen University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Mahnken, Andreas H."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2010,"date_issued":"2010","date_published":"2010","updated_at":"2026-07-30T19:40:42Z","subjects":["info:eu-repo/classification/ddc/610","Spiral-CT","Computertomographie","Angiographie","Framingham-Studie","Herzkrankheit","Koronare Herzkrankheit","Medizin","CT","angiography","coronary artery disease","heart","computed tomography"],"languages":["ger"],"rights":["info:eu-repo/semantics/openAccess"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-114056%22"],"render_values":[{"text":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-114056%22","href":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-114056%22","code":true}]}]},"links":{"outbound_url":"https://publications.rwth-aachen.de/record/51804","outbound_label":"Repository record","outbound_source":"dc:identifier"},"source_record":{"url":"https://publications.rwth-aachen.de/oai2d?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Apublications.rwth-aachen.de%3A51804","prefix":"oai_dc"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Mahnken, Andreas H."]},{"key":"dc:creator","label":"Author","values":["Au, Michael Roland"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:coverage","label":"Dc Coverage","values":["DE"]},{"key":"dc:date","label":"Dc Date","values":["2010"]},{"key":"dc:publisher","label":"Institution","values":["Publikationsserver der RWTH Aachen University"]},{"key":"dc:relation","label":"Dc Relation","values":["info:eu-repo/semantics/altIdentifier/urn/urn:nbn:de:hbz:82-opus-32491"]},{"key":"dc:type","label":"Dc Type","values":["info:eu-repo/semantics/doctoralThesis","info:eu-repo/semantics/publishedVersion"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["info:eu-repo/classification/ddc/610","Spiral-CT","Computertomographie","Angiographie","Framingham-Studie","Herzkrankheit","Koronare Herzkrankheit","Medizin","CT","angiography","coronary artery disease","heart","computed tomography"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["ger"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/openAccess"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://publications.rwth-aachen.de/record/51804","https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-114056%22"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["AIMS: Cardiac multi-detector row computed tomography (MDCT) angiography has shown high levels of sensitivity and especially negative predictive value regarding the diagnosis of coronary artery disease (CAD) especially in patients with a low pre-test probability. This study was designed to determine the value of a 64-slice-MDCT scanner in comparison to invasive coronary angiography for the detection of CAD in a population of symptomatic patients.MATERIAL AND METHODS: 50 patients with suspected CAD underwent conventional coronary angiography and ECG-gated cardiac 64-slice-MDCT angiography. Blinded patient- and segment-based analysis was performed for the detection of stenoses '70% of the vessel lumen. Sensitivity, specificity, positive and negative predictive values and inter-rater agreement were calculated.RESULTS: 94.3% of all coronary segments were assessable by MDCT angiography. Patient-based (segment-based) analysis revealed a sensitivity of 97.7% (86.6%), specificity of 50.0% (95.7%) positive predictive value of 93.5% (76.6%) and negative predictive value of 75.0% (97.8%) considering the invasive coronary angiography as the diagnostic gold standard for CAD.CONCLUSION: In this patient collective 64-slice-MDCT coronary angiography is not yet ready to replace invasive coronary angiography in a population of symptomatic patients. However it can be expected, that by technical progression of multi-detector row computed tomography, MDCT will become a significant, additional tool in risk evaluation of CAD."]},{"key":"dc:source","label":"Dc Source","values":["Aachen : Publikationsserver der RWTH Aachen University II, 82 S. : Ill., graph. Darst. (2010). = Aachen, Techn. Hochsch., Diss., 2010"]},{"key":"dc:title","label":"Title","values":["Diagnostischer Wert der 64-Zeilen-Mehrschichtspiral-Computertomographie des Herzens bei symptomatischen Patienten"]}]}],"canonical_facts":{"dc:contributor":["Mahnken, Andreas H."],"dc:coverage":["DE"],"dc:creator":["Au, Michael Roland"],"dc:date":["2010"],"dc:description":["AIMS: Cardiac multi-detector row computed tomography (MDCT) angiography has shown high levels of sensitivity and especially negative predictive value regarding the diagnosis of coronary artery disease (CAD) especially in patients with a low pre-test probability. This study was designed to determine the value of a 64-slice-MDCT scanner in comparison to invasive coronary angiography for the detection of CAD in a population of symptomatic patients.MATERIAL AND METHODS: 50 patients with suspected CAD underwent conventional coronary angiography and ECG-gated cardiac 64-slice-MDCT angiography. Blinded patient- and segment-based analysis was performed for the detection of stenoses '70% of the vessel lumen. Sensitivity, specificity, positive and negative predictive values and inter-rater agreement were calculated.RESULTS: 94.3% of all coronary segments were assessable by MDCT angiography. Patient-based (segment-based) analysis revealed a sensitivity of 97.7% (86.6%), specificity of 50.0% (95.7%) positive predictive value of 93.5% (76.6%) and negative predictive value of 75.0% (97.8%) considering the invasive coronary angiography as the diagnostic gold standard for CAD.CONCLUSION: In this patient collective 64-slice-MDCT coronary angiography is not yet ready to replace invasive coronary angiography in a population of symptomatic patients. However it can be expected, that by technical progression of multi-detector row computed tomography, MDCT will become a significant, additional tool in risk evaluation of CAD."],"dc:identifier":["https://publications.rwth-aachen.de/record/51804","https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-114056%22"],"dc:language":["ger"],"dc:publisher":["Publikationsserver der RWTH Aachen University"],"dc:relation":["info:eu-repo/semantics/altIdentifier/urn/urn:nbn:de:hbz:82-opus-32491"],"dc:rights":["info:eu-repo/semantics/openAccess"],"dc:source":["Aachen : Publikationsserver der RWTH Aachen University II, 82 S. : Ill., graph. Darst. (2010). = Aachen, Techn. Hochsch., Diss., 2010"],"dc:subject":["info:eu-repo/classification/ddc/610","Spiral-CT","Computertomographie","Angiographie","Framingham-Studie","Herzkrankheit","Koronare Herzkrankheit","Medizin","CT","angiography","coronary artery disease","heart","computed tomography"],"dc:title":["Diagnostischer Wert der 64-Zeilen-Mehrschichtspiral-Computertomographie des Herzens bei symptomatischen Patienten"],"dc:type":["info:eu-repo/semantics/doctoralThesis","info:eu-repo/semantics/publishedVersion"]},"updated_at":"2026-07-30T19:40:42Z"}