Effekte der Inhalationsanästhetika Isofluran und Xenon auf die systolische und diastolische Ventrikelfunktion während Myokardischämie

BACKGROUND: Only a few studies investigated the effects of xenon and isoflurane on the systolic and diastolic function. Especially the informations on the impact of these anethestic agents on animals or humans with impaired left ventricular function are deficient. Both agents demonstrated cardioprotective properties but differed in their negative inotropic action.METHODS: 27 thiopental anesthetized pigs were investigated in an open-chest model with 60 minutes of coronary occlusion (LAD) to induce myocardial ischemia. After first measurements, anesthesia was supplemented by 0,55 MAC of xenon or isoflurane with concomitant reduction of thiopental. A third group with unchanged thiopental dosage served as a control group. Hemodynamics and load independent indices of left ventriculare systolic and diastolic function were assessed by conductance catheter.RESULTS: Xenon and isoflurane did not impair cardiac output or arterial pressure, whereas xenon increased afterload. Nevertheless, both drugs demonstrated negative inotropic effects. Xenon affected the active relaxation and compliance significantly. Ischemia impaired global hemodynamics in the control group, while contractitily was unchanged and diastolic function woresened. In contrast to xenon, isoflurane affected global hemodynamics as well as the indices of the systolic ventricular function. Both drugs xenon and isoflurane impeded diastolic dysfunctions.CONCLUSION: Isoflurane and xenon demonstrated functional cardioprotective properties. Relevant differences unmasked during ischemia and assumed maintained contractile reserve during xenon anesthesia.

Grantor dc:publisher

Publikationsserver der RWTH Aachen University

Year dc:date

2009

Author dc:creator

• Fischer, Simone Stephanie

Contributors dc:contributor

• Rossaint, Rolf

• info:eu-repo/classification/ddc/610
• Isofluran
• Xenon
• Ischämie
• Medizin
• Kardioprotektion
• Conductance Katheter
• Ventrikuläre Funktion
• cardioprotection
• ventricular function
• conductance catheter

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

ger

Identifier

https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-113513%22

OAI record oai:identifier

https://publications.rwth-aachen.de/oai2d?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Apublications.rwth-aachen.de%3A51201