Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"cardioprotection"”.
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Novel Strategies in Cardioprotection against Ischemia/Reperfusion Injury
… dose, induced powerful acute and delayed cardioprotection against I/R injury in an in vivo rabbit model via opening of mitoKATP channels. The acute cardioprotective effect of sildenafil was dependent on activation of protein kinase C in rabbits. Moreover, we observed that sildenafil …
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k-Opioid Receptor Dependent Cardioprotection in the Rat
… indicate that k-opioid receptor dependent cardioprotection is mediated through a PKC-dependent modification of the myofilaments which slows the utilization of ATP by the actomyosin ATPase.</p>
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PKCε and cardioprotection : an exploration of putative mechanisms
Recent studies have investigated the underlying regulatory mechanisms that may explain the cardioprotective role of PKCε. Sub-proteome analysis has identified interactions between activated PKCε and various mitochondrial proteins, which orchestrate mitochondrial homeostasis, including proteins …
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The role of melatonin in red wine-induced cardioprotection
… regular moderate consumption of red wine confers cardioprotection. However, the exact components in red wine that confer this effect are unclear. Previous studies performed in our laboratory suggest that neither the well-known polyphenol resveratrol nor alcohol (12%) present in red wine contribute …
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Stabilization of the Cardiac Nervous System During Cardiac Stress Induces Cardioprotection
… can affect neural-myocyte interactions to induce cardioprotection. Thoracic spinal cord stimulation (SCS) is recognized for its anti-anginal effects and ability to reduce apoptosis in response to acute MI, primarily via modulation of adrenergic efferent systems. The data presented here suggest …
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Myocardial ischemia-reperfusion and cardioprotection. A study with microdialysis in a porcine model.
The studies in this thesis are based on questions raised in the clinical setting. Perioperative myocardial ischemia occurs more often than recognized. This may lead to myocardial infarction, increased morbidity, mortality, and health care costs. In the first study, myocardial metabolism was …
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The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection
… and chronic consumption of red wine confers cardioprotection. Melatonin, present in wine, may contribute to this cardioprotective effect. Melatonin confers cardioprotection via the activation of tumor necrosis factoralpha (TNF-α) and the signal transducer and activator of …
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Divergent Roles of PI3K and Akt in Rapamycin-induced Cardioprotection against Ischemia-Reperfusion Injury
Coronary heart disease (CHD) is one of the leading causes of death every year with nearly three-fourths of all deaths caused by the disease. The challenge scientists are facing today is discovering new drugs to protect the heart against cellular damage caused by ischemia-reperfusion injury (I-R …
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Long-term cardioprotection with phosphodiesterase-5 inhibition against ischemia-reperfusion injury: Role of nitric oxide.
… To evaluate the role of nitric oxide (NO) in cardioprotection, a non-selective blocker of nitric oxide synthase, L-NAME (15 mg/kg, iv) was administered 10 minutes prior to I/R. The results show significant reductions in infarct size in hearts treated with sildenafil and vardenafil as compared …
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The Novel Role of Hematopoietic Lyn Substrate-1 Associated Protein X-1 in Cardiac Contractility and Cardioprotection
… HAX-1 in the regulation of calcium kinetics and cardioprotection, HAX-1 over-expression and HAX-1 heterozygous deficient mouse models were used in the present study for the examination of alterations in basal contractile performance and recovery after ischemia/reperfusion injury by HAX-1.</p><p> …
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TRANSCORONARY COOLING AND DILUTION FOR CARDIOPROTECTION DURING REVASCULARISATION FOR ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION: THE STEMI-COOL PILOT STUDY.
… ischaemia and transient reperfusion prior to cardioprotection. Transcoronary haemodilution may also reduce RI by effectively slowing reperfusion. We developed a novel, simple method combining transcoronary cooling and dilution (TCCD) to reduce RI during pPCI. Methods: STEMI-Cool is a …
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Role of the SAFE pathway and the mitochondria in HDL cholesterol (and its constituent sphingosine-1-phosphate) induced cardioprotection
… been identified as a key signalling pathway in cardioprotection, although the end effector remains unclear.
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The role of the arterial glycocalyx in sphingosine-1- phosphate induced cardioprotection in the isolated heart of the Wistar rat
… Therefore, we hypothesized that S1P-induced cardioprotection is mediated by modulation of the glycocalyx during I/R in the isolated rat heart. Methods: Isolated male Wistar hearts were perfused on a Langendorff system with Krebs-Henseleit buffer via retrograde perfusion at constant …
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The role of the large conductance Ca2+-activated K+ channel in adenosine receptor-mediated cytoprotection
… cell line is increasingly used for studies into cardioprotection, as these cells display similar properties to primary cardiomyocytes. Adenosine receptors are well known mediators of cardioprotection and trigger effectors such as the mitochondrial KATP channel – however, the role of the …
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Preconditioning and augmented preconditioning via manipulation of metabolic and signalling pathways in the rat heart
… signalling events are known to trigger this cardioprotection. The purpose of this study was to investigate the metabolic and intracellular signalling events which occur during ischaemic preconditioning and their effects on improvement of contractile recovery following an ischaemia/reperfusion …
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Gender differences in aortic endothelial function in a rat model of streptozotocin-induced diabetes : possible role of superoxide and cyclooxygenase
… underlying the loss of this gender based cardioprotection in premenopausal diabetic women. The objectives of this study were to investigate whether there is a gender difference in the aortic endothelial function in · streptozotocin (STZ, 58 mg/kg, iv)-induced diabetic rats, and the …
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THE INTERPLAY BETWEEN ESTROGENS AND THE NITRIC OXIDE SYSTEM IN CARDIAC FUNCTION AND STRUCTURE
… literature demonstrating a role of estrogens in cardioprotection. Sex differences in mortality after myocardial infarction tell the story since data show a worse prognosis of death post-myocardial infarction for women (38% within the first year) compared to men (25% within the first year).
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Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries
… and ischaemic postconditioning induced cardioprotection is unknown. Hypothesis: Activation of the STAT-3 is required for S1P preconditioning and ischaemic postconditioning.
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