Publikationsserver der RWTH Aachen University
Einfluss verschiedener venöser Druckniveaus auf den Hämofiltrations-Verlauf unter In-vitro-Bedingungen
Abstract
dc:descriptionMain factors for the overall performances of haemofilters are membrane features and filter durability without clogging/clotting of capillaries. The venous line resistance is a powerful force for net filtrate flux resulting in haemoconcentration and thus is enhancing the phenomenon of membrane clogging. Therefore, we hypothesized that catheter type, as it is associated with venous line resistance, contributes to the extent in which filter longevity and filtration performance are restricted due to blocked hollow fibres. Heparinized porcine blood (5IU/ml) was circulated in an in vitro system for haemofiltration. Three different sizes of catheters for peripheral vein access were alternately inserted into the circuit for blood return from the filter to the reservoir. To produce pressure levels lower than commonly induced by Sheldon catheters, a 14G-vygonuele was used. Pressure levels standard for 11-12 French catheters were provided by 16G-vygonuele. To produce pressure levels common for low-French or three lumen catheters, a shorted 18G-vygonuele was used. The respective pressure levels attained were compared with respect to the overall filtration performance (system pressures, haemocompatibility and sieving coefficients). Catheters of 14 and 16G enabled transiently maximal blood flow (Qb)/filtration rates (Qf) of 300/60 ml/min and continuous filtration with Qb/Qf of 200/40 ml/min. The shorted 18G catheter reduced maximal blood flow rates down to Qb/Qf of 200/40 ml/min and continuous flow rates down to Qb/Qf of 125/25 ml/min. At the end, median values for blocked hollow fibres were 35% in the 14G-group, 40% in the 18G-group and 70% in the 16G-group. Haemocompatibility appeared to be higher in the 14G-group with respect to various parameters when compared with the other groups. The flow resistance by the catheter chosen for haemofiltration clearly influenced the filtration performance. Thus, investigations focused on compatibility of catheter type as it related to venous line resistance levels with the particular method of renal replacement therapy that should be performed. This point could be crucial in reducing filter clogging and haemostasis during CVVH.
Degree
thesis:*- Grantor dc:publisher
- Publikationsserver der RWTH Aachen University
- Year dc:date
- 2008
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Küpper-Portz, Britta Gertrud Aloysia
- Contributors dc:contributor
-
- Rossaint, Rolf
Subjects
dc:subject × 7Rights
dc:rights- Statement dc:rights
-
- info:eu-repo/semantics/openAccess
- Language dc:language
- ger