Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"xenotransplantation"”.
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Untersuchungen zur Herztransplantation im Langzeitmodell am Schwein und chirurgische Aspekte zur Xenotransplantation des Schweineherzens
… zu Abknickungen nach der HTx führen. Bei der Xenotransplantation ist daher die biatriale Technik zu bevorzugen.
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Histopathology of livers and native organs of recipients following genetically-engineered pig-to-baboon liver xenotransplantation
In project 1, orthotopic liver transplantation was carried out in baboons using wild-type (WT,n=1) or genetically-engineered (GE) pigs (alpha1,3-galactosyltransferase gene-knockout, GTKO), n=1; GTKO pigs transgenic for human CD46, n=7). Biopsies of GE livers were obtained pre-transplantation, 2h …
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Porcine islet encapsulation for treatment of type-1 diabetes using precision particle fabrication method
… because of the limited donor availability. Xenotransplantation using porcine islet is a good alternative treatment of T1D. Porcine islet is an ideal substitute of beta cell function for human islet for several reasons: availability, compatibility and functional similarity to human islets. In …
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Molecular Characterization and Inhibition of Antibodies Elicited Against Galactosyltransferase Knockout Pig Xenografts
… were still on the transplant waiting list. Xenotransplantation, the transplantation of cells and/or organs from a member of another species, is both a viable supplement for, and bridge to, allotransplantation. Pigs are the favored organ donor because they: 1) breed and grow rapidly, 2) can …
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Study of Physiologic and Immunologic Incompatibilities of Pig to Human Transplantation
… donor allografts. Pig to human transplantation, xenotransplantation, could potentially solve this problem if physiologic and immunologic incompatibilities are overcome. Genetic modifications of pigs have proven valuable in the study of xenotransplantation by improving pig to human compatibility. …
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Phylogenetic distribution of CMP-Neu5Ac hydroxylase (CMAH), the enzyme synthetizing the pro-inflammatory human xeno-antigen Neu5Gc
… inflammation, arthritis andcancer. Likewise, xenotransplantation of organs producing Neu5Gc can result ininflammation and organ rejection. Therefore, knowing what animal species contain afunctional CMAH gene, and are thus capable of endogenous Neu5Gc synthesis, haspotentially far-reaching …
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The susceptibility of baboons to the novel immunosuppressant, FTY720
… This has resulted in a renewed interest in xenotransplantation. Organs from non-human primates would arguably be the organs of choice but ethical consideration prevents this. The transplantation of organs from pigs or sheep to humans i.e. xenotransplants, results in hyperacute rejection. The …
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Developing Zebrafish as an In Vivo Model to Screen Compounds for Anti-Cancer Activity in Human Breast Cancer
… expand the applicability of <em>in vivo</em> xenotransplantation of human BC cells in transgenic zebrafish to screen potential chemotherapeutics for toxicity and efficacy. For xenotransplantation, MCF-7, BT-474, and MDA-MB-231 BC cells were used to canvas the benign and malignant types of BC, …
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Intravitalmikroskopische und immunhistochemische Untersuchungen zur Wirkung poly- und monoklonaler anti-Lymphozytenantikörper am konkordanten, xenogenen Primatenmodel
… menschlicher Lymphozyten bei der konkordanten Xenotransplantation und 6.gibt es diesbezüglich Unterschiede zwischen ATG-Fresenius und ATG-Mérieux? 7.Beeinflusst die Behandlung mit anti- IL-2 Rezeptor Antikörpern das Adhäsionsverhalten menschlicher Lymphozyten bei der konkordanten …
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[alpha](1,3)galactosyltransferase mediated gene therapy for cancer: developing new models and improving on existing ones
… biology of alpha(1,3) galactosyltransferase in xenotransplantation experiments. Therefore, we have developed a gastrointestinal stromal tumor, CA320M, derived from C57/BL6 alpha(1,3)galactosyltransferase knock-out mice. The approach, however, is based in part on the sensitivity of tumor cells to …
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Deciphering tranSNPs: functional genetic variants shaping protein output and cancer-related phenotypes
… Indeed, autophagy, cell competition, and in vivo xenotransplantation were significantly affected across TT and AA clones homozygous for the SNP. Furthermore, analysis of TCGA colorectal cancer data revealed that rs1053639 alleles are prognostic for disease-free interval (DFI), and we uncovered …
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The Generation of a Candidate Axial Precursor in Three Dimensional Aggregates of Mouse Embryonic Stem Cells
… tissues. Additionally, this work establishes a xenotransplantation assay for testing the functional properties of in vitro-derived NMp populations in the chicken embryo and applies it to NMps from gastruloid cultures. The results of this assay show that gastruloids are a credible source of NMps …
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Ethical issues relating to the 'donation' of human and animal organs for transplantation
… The third chapter is an investigation into xenotransplantation - the use of organs from nonhuman animals. I argue that using animals `just because' they are animals is ethically indefensible. Instead I attempt to justify the killing of (some) animals as organ donors on the grounds that their …
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Interleukin-15 and [alpha](1,3)galactosyl-expressing vaccine combination therapy for melanoma
… immune response observed in humans after xenotransplantation is mainly induced by the alpha(1,3)Galactosyl (alphaGal) epitopes expressed on xenografts and the pre-existing anti-alphaGal antibodies that recognize these epitopes. Based on this hyperacute rejection, we hypothesized that human …
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Evidence of Extrahepatic Sites of Replication of the Hepatitis E Virus in a Swine Model
… important implications for HEV pathogenesis, xenotransplantation, and the development of an in vitro cell culture system for HEV.
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Characterisation of human Haematopoietic Stem Cell differentiation and exit from quiescence at single cell resolution
… assays and single cell RNA-sequencing with xenotransplantation assays to profile single human HSC properties in the purest HSC compartment reported to date (CD49+ HSCs) and to understand when the first steps of lineage restriction occur during HSC differentiation. Moreover, I use an in-vitro …
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Targeted magnetic hyperthermia for lung cancer
… expression, mammosphere formation and in vivo xenotransplantation, indicated that magnetic hyperthermia reduced or, in some cases, eliminated the CSC sub-population in treated cells. Magnetic hyperthermia demonstrated pleiotropic effects, inducing acute necrosis in some cells while stimulating …
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In-vitro-Modell eines xenogenen Systems: Chronische Wirkungen induzierter versus präformierter Antikörper auf Herzmuskelzellkulturen von neonatalen Ratten
Fragestellung: Die klinische Herz-Xenotransplantation scheint aufgrund vielfältiger wissenschaftlicher Fort-schritte wahrscheinlicher zu werden, jedoch könnten präformierte natürliche Antikörper, die ohne vorausgegangene Sensibilisierung im Blut vorhanden sind und Antigene fremder Spezies erkennen, …
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Eine neue Technik zur myokardialen Protektion von marginalen Spenderherzen : Experimente am Hausschwein im Langzeitmodell
… „Assist Devices“, das „tissue engineering“, die Xenotransplantation und auch die Verbesserung der Pharmakotherapie. <br>Als weiteren Ansatz befassten sich unsere Studien mit der Verwendung von sogenannten marginalen Spenderherzen, das heißt von Herzen, die bis kurz vor der Organentnahme völlig …
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