Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 111 for “"virus replication"”.
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Initial Stages of Hepatitis B Virus Replication
… of HBV Core Particle in Various Stage of DNA Replication Inside of hepatitis B virus (HBV) core particle, pgRNA is reverse transcribed by HBV DNA polymerase into minus-strand DNA and pregenomic RNA (pgRNA) is degraded concomitantly by RNase H activity of DNA polymerase. Then, plus-strand DNA …
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The Role of NS1-BP in Influenza Virus Replication
Influenza A viruses are negative-sense, segmented RNA viruses which cause about 500,000 deaths worldwide per year. Genomic studies have shown that the non-structural protein (NS1) of influenza A virus is a major virulence factor that is essential for pathogenesis. NS1 is a multifunctional protein …
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Roles of Interferon Lambda on Hepatitis B Virus Replication
"Background/Aims: Chronic hepatitis B virus (HBV) infection is a major cause of liver disease. Only interferon-α (IFN-α) and the nucleosidic inhibitors of the viral polymerase, lamivudine and adefovir, are approved for therapy. However, these therapies are limited by the side effects of interferon …
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Investigations of the molecular determinants of maize streak virus replication
Geminiviruses replicate via a rolling circle mechanism, which initiates at the origin of replication located within the long intergenic region (LIR). The viral replication associated-protein (Rep) in conjunction with the host's DNA replication machinery is responsible for the initiation and …
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Mechanism of suppression of Banzi virus replication in Aedes albopictus cells
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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MIR-122 and DDX6 facilitate hepatitis C virus replication via independent mechanisms
… 130 million people are infected with hepatitis C virus (HCV) that leads to chronic hepatitis. Current therapy is limited in its efficacy; hence better interventions are required. A detailed understanding of the host factors involved in HCV replication such as miR-122 and DEAD-box RNA helicase, …
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AMP-activated protein kinase-mTOR signaling pathway and hepatitis B virus replication
B형간염 바이러스(hepatitis B virus, HBV)는 Hepadnaviridae family에 속하며, genome 크기가 약 3.2kb의 작은 DNA 바이러스이다. 전 세계적으로 약 3억 5천만 명 이상이 만성으로 HBV에 감염되어 있다. HBV는 급성과 만성 B형 간염을 일으키며 만성 B형 간염 환자는 간경변이나 간암으로 발전할 가능성이 높다. AMP-activated protein kinase(AMPK)는 ATP 소비와 생성의 균형을 위해서 필요한 에너지 센서 단백질이다. Hepatitis C virus(HCV)의 …
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The role of -2/-1 ribosome frameshifting mechanism in PRRS virus replication
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01
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Functional Analysis of the Human Cytomegalovirus Ul82 Gene Product PP71 Protein During Virus Replication
Human cytomegalovirus (HCMV) is a beta-herpesvirus that infects the majority of the human population. Although primary infection is usually asymptomatic in immunocompetent individuals, HCMV infection can lead to severe disease in immunosuppressed individuals including neonates, transplant …
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In Vitro and In Vivo Effects of Espirito Santo Virus on Dengue Virus Replication
Arboviruses have been one of the leading causes of morbidity and mortality worldwide for centuries (Morens et al., 2004). Dengue virus (DENV), Zika (ZIKV), Chikungunya (CHIKV) and West Nile virus (WNV) are some of the medically important arboviruses transmitted by mosquitoes. Dengue is one of the …
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Unraveling the cellular and viral genes important for fully productive Marek’s disease virus replication
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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The Role Of The Membrane Proximal Region Of The M2 Cytoplasmic Tail In Virus Replication
Influenza A virus encodes M2, a proton channel that has been shown to be important during virus entry and assembly. The primary aim of this thesis was to investigate the role of the membrane proximal region, residues 46-69, of the M2 cytoplasmic tail during virus replication. A cholesterol …
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Studies into the role of capsid serine/threonine residues in HIV core stability and virus replication.
… of CA from the core is unknown. Cores from virus containing mutations in CA that show altered core stability, and release CA from the core at rates faster or slower than wild type (WT) virus demonstrate blocks in replication during reverse transcription and nuclear translocation. How the CA …
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Design of a Tetracycline Operon Inducible System for the Control of Vaccinia Virus Replication: Implications for Vaccine Development
<p>The use of vaccinia virus (VACV) as a vaccine resulted in the eradication of smallpox in 1979. Characteristics that contribute to the effectiveness of VACV as a vaccine and viral vector include its ability to elicit strong, long-lived humoral and cell-mediated immune responses as a …
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The effect of mutant replication initiation proteins and antisense RNA to the gene on maize streak virus replication
Maize (Zea mays L) is a major crop plant belonging to the family Poaceae, which includes other important cereals such as wheat, rice, barley and oats (Kellogg, 1998). Other grass crops are rye, common millet, finger millet, teff, sugarcane and sorghum. Many of these are important food crops in most …
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RESISTANCE TO VESICULAR STOMATITIS VIRUS IS INTRINSIC TO PC3 PROSTATE CANCER CELLS AND CAUSES INHIBITION OF EARLY STEPS OF THE VIRUS REPLICATION CYCLE
… the oncolytic activity of vesicular stomatitis virus (VSV). In Chapter 1 I analyzed the timing of the different steps of the virus replication cycle in PC3 prostate cancer cells (VSV-resistant cells) to LNCaP prostate cancer cells (VSV-sensitive cells). My experiments revealed that several early …
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A Study of Human Coronavirus NL63: Characterization of Virus Replication, Targeting of Papain-Like Protease 2 by Antivirals and Probing Virus Mediated Innate Immune Antagonism
… in children, elderly, and the immunocompromised. Virus infection is the primary cause of acute respiratory tract infections. Infection with coronaviruses can cause disease ranging from common colds to severe acute respiratory syndrome. Currently no coronavirus-specific antivirals are available. …
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The transmitted HIV-1 subtype C: characterization of the transmitted/founder full-length virus genome and the influence of early immune selective pressure on virus replication
… early evolution of transmitted/founder subtype C virus sequences was investigated to determine the location and frequency of immune selection, and the impact of early immune escape mutations on viral replicative capacity. Single-genome amplified env sequences from 26 acutely-infected women were …
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