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Showing 1 to 20 of 90 for “"uracil"”.
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Dynamics of UV -Excited Uracil, Thymine, and Cytosine
… how these dimers form. The pyrimidine bases (uracil, thymine, and cytosine) have been studied with ab initio multiple spawning molecular dynamics and high level electronic structure methods. This work has involved both gas-phase and aqueous dynamics as well as simulation of the time-resolved …
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Isolation and Characterization of the Xiphophorus Maculatus Uracil-DNA Glycosylase Gene
No abstract prepared.
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Synthesis of novel 5,6-disubstituted derivatives of uracil as potential drugs
… of novel 5,6-disubstituted derivatives of uracil as potential drugs In this thesis, uracil was used as the core structure given its many biological activities that were reported such as antitumor, antiviral, antibiotic, hypoglycemic, diuretic and many others. The work was focused on the …
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Study of Low Energy Electron-Impact Induced Ionization and Fragmentation of Uracil
… impact induced ionization and fragmentation of uracil. The apparatus consists of a pumped vacuum system with an expansion chamber, a collision chamber and a flight tube. A beam of uracil is generated in the expansion chamber, passes through a skimmer and crossed with a pulsed beam of low energy …
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Dual Targeting of Tumor Angiogenesis and Chemotherapy By Endostatin- Cytosine Deaminase-Uracil Phosphoribosyltransferase
… linked endostatin (Endo) to cytosine deaminase-uracilvphosphoribosyl transferase (CD). Endo targets unique tumor endothelial cells toprovide tumor-specific antiangiogenesis activity and also carries CD to the localtumor area, where it serves nontoxic prodrug 5-fluorocytosine (5-FC) …
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Kinetic and Mechanistic Characterization of the Uracil Phosphoribosyltransferase Activity of Bacillus Subtilis PyrR
… 18 +/- 2 muM. There was no detectable binding of uracil or PPi to PyrR, which was consistent with each of the four proposed conformational change models.
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Mechanism of Incorporation and Repair of Uracil At Highly Transcribed Genes In Saccharomyces Cerevisiae
… from the non-canonical residues such as uracil, which are also elevated at highly transcribed regions. Apurinic/Apyrimic or Abasic (AP) sites derived from uracil excision, accumulate at a higher rate in actively transcribed regions of the genome in S. cerevisiae and are primarily repaired …
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Identifizierung und Charakterisierung von thermostabilen Uracil Glykosylasen von Archaeon Methanobacterium thermoautotrophicum und Bakterium Thermus thermophilus
… (BER) vorgeschlagen und die Wirkung von Uracil und T/G, U/G "Fehlpaarungen" spezifischen DNA-Glycosylasen postuliert. Mit dem Ziel das Wissen über U/G und T/G entfernende Enzyme zu vertiefen, lag der Fokus dieser Arbeit in der Isolierung und enzymatischen Charakterisierung …
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Oxidative DNA damage : mutagenic properties of 5-hydorxycytosine, 5-hydroxyuracil and uracil glycol in Eschericia coli
Thesis (Ph. D.)--Massachusetts Institute of Technology, Division of Toxicology, 1998.
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The Loss Of Genomic Uracil Homeostasis And Aid-Dependent Accumulation Of Dna Damage In B Cell Lymphomas
… DNA cytosine deaminase that introduces uracils in immunoglobulin genes. This DNA mutator is required for somatic hypermutation and class switch recombination- processes involved in the affinity maturation and diversification of antibodies. AID, however, can also lead to deleterious …
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The Effect of Activation Induced Cytidine Deaminase Phosphorylation and Herpes Virus Uracil Dna Glycosylase On Antibody Diversification
… locus where it deaminates cytosines to generate uracil residues in DNA. This generates guanine-uracil (U:G) mismatch lesion which are recognized by uracil DNA glycosylase (UNG), a DNA repair enzyme that removes uracil from DNA and triggers downstream repair of the lesion. While UNG is a …
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Computational rationale for the selective inhibition of the herpes simplex virus type 1 uracil-DNA glycosylase enzyme
… the nature of binding of the 6-(4-Alkylanilino)-uracil inhibitors in hsvUDG and hUDG to provide a platform for the development of improved inhibitors.
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Uracil Accumulation Response To Folate Depletion Is A Function Of Dna Repair Imbalance That May Be A Mechanism Of Aging
… determine the gene expression, enzyme activity, uracil level in DNA, and through microbiological assay to determine the folate level, elucidates mechanism of uracil accumulation response to folate depletion. The findings present folate deficiency status affects the uracil DNA glycosylase …
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The Role of Rna and Rna Polymerases in The Aging Process
Radioactive uracil incorporated into the total RNA of old Rhizoctonia solani cells was twofold less than that in young cells, but there was no change in RNA label following a chase with unlabeled uracil. As the concentration of labeled uracil in the medium increased, the amount of uracil label in …
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THE ROLE OF DNA REPAIR IN DNA METHYLATION DYNAMICS
… stem cells. AID deaminates cytosine to uracil and can also deaminate methylcytosine, whereas the primary role of UNG is to maintain the integrity of the genome through erasure of uracil. In this thesis, I have aimed to investigate the role of DNA repair in demethylation. To do this I …
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The Utility of 7-Deazaguanine: Part I. High Affinity, High Fidelity Modules for Supramolecular Chemistry, And, Part II. Molecular Recognition of Uracil and Thymine
A water-soluble analogue of the 2-naphthyl-7-DeG host was synthesized and evaluated as a molecular recognition unit to a thymine (T) bulge of a short 10-bp oligomer. The ligand was found to stabilize the T bulge quite significantly (+7.8°C) relative to the C bulge (3.6°C) and A and G bulges …
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Surface Coverage and Structure of Catalytic Monolayers on Au(111) Electrodes
… Finally, quartz crystal microbalance studies of uracil desorption from Au(111) in neutral solutions indicate that the desorbed mass changes linearly as a function of uracil concentration. This indicates that under these conditions uracil is actually adsorbed in a multilayer. (Abstract shortened …
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INFLAMMATION INDUCED CYTOSINE DEAMINATION DAMAGE IN CANCER ETIOLOGY
… deamination of cytosine and cytosine analogs to uracil and the corresponding uracil analogs. During replication, uracil and uracil analogs codes as thymine, leading to the aforementioned transition mutation. However, inflammation is known to cause a characteristic guanine to thymine transversion …
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