Global ETD Search
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Showing 1 to 13 of 13 for “"tsutsugamushi"”.
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Pulmonary vascular malfunction and inflammation during Orientia tsutsugamushi infection
… caused by infection with the bacterium, Orientia tsutsugamushi. Scrub typhus remains a neglected tropical disease, despite being a tremendous burden in endemic areas. Lung injury is one of the most common pathologies that arise from severe cases of scrub typhus, but the underlying mechanisms are …
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Role of Mincle in Immune Responses to Orientia tsutsugamushi infection
… The causative agent of scrub typhus, Orientia tsutsugamushi, is an obligate intracellular bacterium transmitted via bite of the Leptotrombidium mite (chigger). O. tsutsugamushi replicates in endothelial cells and macrophages (MF) and initial symptoms of infection are nonspecific, including …
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Role of Mincle in Immune Responses to Orientia tsutsugamushi infection
… The causative agent of scrub typhus, Orientia tsutsugamushi, is an obligate intracellular bacterium transmitted via bite of the Leptotrombidium mite (chigger). O. tsutsugamushi replicates in endothelial cells and macrophages (MF) and initial symptoms of infection are nonspecific, including …
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Dysregulated TFH cell and germinal center activation in mice with severe Orientia tsutsugamushi infection
… understudied tropical disease caused by Orientia tsutsugamushi. It is endemic in, but not limited to, the Asia-Pacific region, with about one million cases reported every year. Its high case fatality rates and impact during WWII and the Vietnam War justify vaccine development; however, little is …
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Elucidation of Mechanisms of Host Immunity against Orientia tsutsugamushi in a Newly Developed Murine Model
… obligately intracellular coccobacillus, Orientia tsutsugamushi, is a long neglected but important tropical disease. Orientia tsutsugamushi causes illness in one million people each year, with an additional 1 billion people at risk. Without appropriate diagnosis and treatment, the disease can cause …
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Development of a Murine Model of Severe Scrub Typhus And Its Use to Elucidate the Immune Response to and The Pathology that Occurs during Orientia Tsutsugamushi Infection.
… the obligately intracellular bacterium Orientia tsutsugamushi. Mechanistic studies of immunity have been performed primarily in intraperitoneally inoculated mice in which Orientia is largely confined to the peritoneal cavity rather than causing disseminated endothelial infection and multifocal …
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Establishment and Improvement of Preclinical Murine Models of Severe Scrub Typhus to Define Immune Signatures and Pathogenic Mechanisms
… endemic countries due to infection with Orientia tsutsugamushi (Ot), a seriously understudied intracellular bacterium. Scrub typhus causes 150,000 deaths per year, with an estimated 1 million cases, and a further 1 billion people at risk. No vaccine is available for this reemerging and severely …
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Investigating dynein-based transport of intracellular pathogens
… by the obligate intracellular bacterium Orientia tsutsugamushi, which exploits dynein and microtubules to reach its subcellular niche at the perinucleus. Similarly, the neurotrophic virus Herpes Simplex Virus type 1 (HSV-1) undergoes dynein-dependent movement from the axonal tip of sensory neurons …
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The Influence of Certain Lytic Agents on the Oxygen Consumption of Dog Erythrocytes
… Mice were successfully treated with the dye for Tsutsugamushi disease but subsequently developed anemia (4).
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Trobicúlidos y trombiculiasis en La Rioja
… Coxiella burnetii, Bartonella spp. and Orientia tsutsugamushi in chiggers, and 4) Clinical characterization of trombiculiasis in La Rioja. Our data have shown the coincidence between the seasonality of human and canine cases of trombiculiasis and the presence of larvae over vegetation in …
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The differentiation of non-louse-borne fevers of the typhus group occurring in the United Provinces, India
… six can be classified in the scrub typhus-tsutsugamushi disease group. Four of these were cases of the latter condition, which is now regarded as mite- typhus, a condition which has not been described previously in India. In the re- maining fourteen cases two distinct types of serologi- cal …
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A Study of the Effect of Methylene Blue on Lactate Metabolism of the Dog Erythrocyte
… and Grant (3), while conducting studies on Tsutsugamushi fever, noted that the administration of methylene blue to rats infected with R. nipponica, although apparently cured of the infection, ultimately died as a result of anemia, Struck and Mitchell (4) in 1951 reported that dogs which …
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Scrub typhus: Epidemiology, Diagnosis, Treatment, Prevention and Control in the Asia-Pacific Area and Worldwide
… The antigenic heterogeneity of Orientia tsutsugamushi results in reinfection with scrub typhus. As a neglected disease, there is still a large gap in our knowledge of the disease, as evidenced by the sporadic epidemiology data and other related public health data regarding scrub typhus in …