Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 2242 for “"transcripts"”.
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Farnesylation-dependent regulation of transcripts by PARP13
… mutant (PARP13.1C899s). Most of the transcripts that are regulated in a PARP1 3.1-dependent manner are membrane-associated and require the farnesylation of PARP13.1 for their regulation. These results possibly suggest that localization of PARP1 3.1 to the ER by farnesylation is …
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Human La Function in Expression of Coding Transcripts
… processing and maturation of RNA polymerase III transcripts by binding to the UUU-3'OH trailer in a sequence specific manner. Cytoplasmic La proteins are associated with promoting cap-independent translation from the internal ribosome entry sites (IRESs) of several cellular and viral coding RNAs. …
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Dynamic relocalization of maternal transcripts during oocyte meiotic maturation
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Understanding dialogue: sentiment and topic analysis of dialogue transcripts
The field of natural language processing has had success in analyzing sentiment and topics on written text, but similar analysis on dialogue is more difficult due to the fragmented and informal nature of speech. This work explores sentiment and topic analysis on data from the Switchboard dialogue …
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Small RNAs Regulate Transcription by Interacting with Noncoding RNA Transcripts
… targeted with duplex RNAs have no characterized transcripts in their promoters. I tested the hypothesis that promoter RNA transcripts exist and serve as a substrate for short duplex RNAs to hybridize to and regulate gene expression of adjacent genes. I found previously undiscovered RNA …
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Nanobody-Based Interactomic Studies of Single Transcripts During mRNA Maturation
… of protein factors, which interact with maturing transcripts and each other to form dynamic mRNP complexes. While there are many core, essential mRNP factors, the pathways governing mRNA maturation are not uniform, and different transcripts can be associated with mRNP complexes of dramatically …
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Identification of novel transcripts in hepatocellular carcinoma using RNA-seq
… technologies have helped the finding of novel transcripts by deep RNA sequencing (RNA-Seq). The approach to identify novel transcripts using RNA-Seq has been studied, however, prediction of their functional roles in cancers are not studied thoroughly. Here, I constructed new pipeline to …
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Generating Canonical Sentences from Question-Answer Pairs of Deposition Transcripts
… a particular case, such as testimony of people, transcripts, depositions, memos, and emails. Deposition transcripts are one such type of legal document, which consists of conversations between the different parties in the legal proceedings that are recorded by a court reporter. Court reporting …
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The Making of U.S. Monetary Policy: A Linguistic Analysis of FOMC Transcripts
This dissertation uses 152 verbatim FOMC transcripts (2000–2018) to quantify how leadership and gender shape deliberation and to infer individual policy preferences from what participants say behind closed doors. I build speaker-level measures of participation (speech share and frequency) and …
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Significance of low-abundance transcripts detected in Caenorhabditis elegans muscle SAGE libraries
… tags/~50,000-100,000 tag library). Low-abundance transcripts have typically been overlooked since most are considered experimental or contamination errors. Consequently, research has been focused on transcripts that are most enriched in the particular tissue of interest. Here I focus on the …
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Using Ontology-Based Approaches to Representing Speech Transcripts for Automated Speech Scoring
<p>Text representation is a process of transforming text into some formats that computer systems can use for subsequent information-related tasks such as text classification. Representing text faces two main challenges: meaningfulness of representation and unknown terms. Research has shown evidence …
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Proteins Involved in HDACi Induced Decay of ERBB2 Transcripts in Breast Cancer
… in the 3’untranslated region (UTR) of ERBB2 transcripts are an important component of this transcript decay pathway. Based on these observations, we hypothesize that polyribosomally associated proteins, subject to regulation by HDAC-modulated protein acetylation, bind to the 3’UTR of ERBB2 …
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Dynast: Inclusive and efficient quantification of metabolically labeled transcripts in single cells
… quantify metabolically labeled and splicing transcripts from high-throughput metabolic labeling-enabled scRNA-seq.
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JAZZ’S HIDDEN TRANSCRIPTS: BETWEEN CALIBAN AND COLTRANE CRITICAL IMPROVISATIONAL PEDAGOGY AS PRAGMATIC POLITICS
This project addresses problems of political disengagement, social exclusion, multi-generational poverty, and social injustice in communities left behind by an incomplete democracy, now in acute crisis. Using jazz improvisation as a metaphor for Dewey’s ideals for a thriving and creative American …
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Statistical Models for Gene and Transcripts Quantification and Identification Using RNA-Seq Technology
… to quantify the expression levels of genes and transcripts. Although being effective in many cases, these methods can become ineffective in some other cases, and may even suffer from the non-identifiability problem. A key drawback of these existing methods is that they fail to utilize all the …
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Characterization and Regulation of Insulin-Like Growth Factor-Imrna Transcripts in Myeloid Cells
… fragments corresponding to IGF-I Ea and Eb mRNA transcripts were detected in all murine immune cell types. The identity of these sequences was confirmed by cloning and sequencing. Macrophages had 20 to 40 fold higher levels of IGF-I mRNA than B or T cells and macrophage transcripts initiated …
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p53 nuclear localization control, and p53-dependent regulation of DNA repair gene transcripts
The experiments presented in this thesis use mutation analysis, and study of the cells of mice with a deletion allele for the Trp53 gene, to explore both the regulation of p53, and its downstream functions mediated by specific activation of target genes. Chapter 2 addresses the regulation of …
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Fission Yeast Exon Junction Complex Orthologs Ensure the Maturation of Meiotic Transcripts During Meiosis
… by a concomitant loss of stability of meiotic transcripts and impaired maturation processes such as splicing. We propose that the interaction between Rsf1 and NURS serves to mediate proper meiotic mRNA maturation upon the induction of meiosis.
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