Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 856 for “"transcriptomic"”.
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Transcriptomic profiling of macrophage polarization
… most popularly used platforms for single-cell transcriptomics. I then focus on my work characterizing macrophage polarization and repolarization in vitro, where I performed deep transcriptomic profiling at high temporal resolution as macrophages were polarized with cytokines that drive them …
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Modeling transcriptomic dynamics and epigenomic conservation
Gene regulatory networks control gene expression during various biological processes, including two sets with similarity: differentiation processes of embryonic stem (ES) cells and embryo development processes. This thesis work centers on two aspects in analyses of such gene expression patterns: …
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Transcriptomic Profiling of Hypothalamic Kiss1 Neurons
… and AVPV Kiss1 (Kiss1AVPV) neurons, unbiased transcriptomic profiling was done using RNA-sequencing on pools of Kiss1 neurons obtained by enzymatic dissociation of brain tissue. Principal component analysis revealed a clear clustering of Kiss1AVPV neurons from the Kiss1ARC neurons, while …
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Genomic and Transcriptomic Landscape of Colorectal Premalignancy
… and chromosomally unstable (CIN). Genomic and transcriptomic characterization of CRC has emerged from large-scale studies in recent years due to the advancement of next-generation sequencing technologies. These studies have identified key genes and pathways altered in CRC and provided insights …
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Transcriptomic analysis of pancreatic cells in zebrafish
… the first part of my thesis was to determine the transcriptomic signatures of each pancreatic cell type in zebrafish in order to identify novel cell type-specific regulatory genes that might be crucial for their differentiation and/or physiology. Pancreatic acinar cells, ductal cells as well as …
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Transcriptomic and proteomic dysregulation in neuropsychiatric disorders
… disorder development. We used a combination of transcriptomic and proteomic methods, leveraging large RNA-Seq and microarray datasets to circumvent issues with power for the proposed analyses. A literature summary on previously identified transcriptomic and proteomic dysregulations in …
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Transcriptomic analysis of sugar accumulation in sorghum
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms
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Transcriptomic predictors of outcomes in acute infection
… deconvolution techniques I examined the host transcriptomic response to infection in peripheral blood. I sought to understand how the presence of infection, site of infection, and type of pathogen affected gene expression and the implications of these for the underpinning biology. I …
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Evolution and domestication of Saccharum using transcriptomic analyses
Made available in DSpace on 2015-01-21T19:59:08Z (GMT). No. of bitstreams: 2 Jie Alojado_Arro.pdf: 4749179 bytes, checksum: cfc9857724097c1265668680f6d42a11 (MD5) Arro_Jie_Dissertation2014.docx: 5414295 bytes, checksum: dcc39b1790b35647eda126450f7df157 (MD5)
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Understanding Disease and Disease Relationships Using Transcriptomic Data
As the volume of transcriptomic data continues to increase, so too does its potential to deepen our understanding of disease; for example, by revealing gene expression patterns shared between diseases. However, key questions remain around the strength of the transcriptomic signal of disease and the …
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Transcriptomic profiling of human cells destined for therapeutic applications
… chapter describes my characterization of the transcriptomic profiles of BMAC from OA patients and healthy donors. The results suggest overexpression of immune related pathways in BMAC samples from OA patients compared to samples from non-OA donors. Since pro-inflammatory cytokines play a role …
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Transcriptomic Insights into the Morphological Variation Present in Bromeliaceae
… storage during CAM photosynthesis. Lastly, transcriptomics differences indicate different drought survival strategies, with the most extreme differences occurring between Aechmea nudicaulis and Tillandsia gardneri. This study identified transcripts related to the morphological gradient and …
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Transcriptomic Signatures of Projection Class Neurons for Vocal Control
<p>Vocal learning is the ability to modify acoustic structure and syntax of vocalizations. This rare trait is thought to have independently evolved three times in birds and five times in mammals. Vocal learning species exhibit an underlying convergence in brain circuitry, including a direct, …
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Integrative transcriptomic approaches to analyzing plant co-expression networks
It is well documented that transcriptionally coordinated genes tend to be functionally related, and that such relationships may be conserved across different species, and even kingdoms. (Ihmels et al., 2004). Such relationships was initially utilized to reveal functional gene modules in yeast and …
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Applicability and limitations of transcriptomic pipelines in livestock species
… understanding organisms' responses to disease. Transcriptomic datasets offer a contextualized snapshot of the steady-state levels of RNA from the biological sources from which they are derived, allowing for the identification of variants affecting gene regulation. This information can be …
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Deconvolution of spatiotemporal transcriptomic heterogeneity in the glioblastoma ecosystem
Glioblastoma (GBM) is the most common and lethal primary brain malignancy in adults, characterized by therapeutic resistance and inevitable relapse. Major clinical challenges are imposed by extensive intra-tumoral heterogeneity, diffuse infiltrative growth of the tumor, and bi-directional …
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Transcriptomic Insights into the Diplontic Life History of Diatoms
<p>An organism's life cycle is the direct result of its evolutionary history and represents a fundamental aspect of its ancestry and ecology. Yet the process of linking alternating life-history stages has proven to be challenging, if not impossible in some cases. Diatoms (Bacillariophyceae) are no …
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Transcriptomic studies of protein homeostasis perturbations in neurodegenerative disorders
… Our analysis was initially carried out on transcriptomic profiles of bulk tissue data, and was subsequently tailored to single-cell RNA sequencing datasets, in order to verify how working at different resolutions would affect our findings. Dimensionality reduction and clustering techniques …
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Stitching and sketching large-scale single-cell transcriptomic data
… and interpretation of large-scale single-cell transcriptomic data sets.
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Streamlining and standardizing transcriptomic analysis in Amgen process development
… and synthesizing biological data; such as transcriptomic (gene expression), proteomic (protein levels), or metabolomic (metabolite levels). This thesis describes a streamlined workflow for analyzing transcriptomic data. This streamlined workflow not only reduced the barrier to conducting …
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