Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 149 for “"transactivation"”.
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Cis and Trans, p53 and NF-kB rules of transactivation
… of target genes, through highly regulated transactivation specificities. TAp53 is a tumour suppressor activated upon genotoxic and physiological stress and involved primarily in deciding senescence, cell cycle arrest or apoptosis as cell fate; the NF-kB proteins are involved in cell …
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Electrostatic properties at the interface of p53 Transactivation domain binding
… 2 (MDM2). p53 is widely studied, and the p53 transactivation domain (TAD) is disordered and binds to many structurally diverse partners, making this protein domain a useful model for probing the role of electrostatic interactions formed by IDPs at protein-protein binding interfaces. We found …
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Characterisation of the molecular mechanisms of EGFR signal transactivation in human cancer
… epithelial cells metalloprotease-dependent transactivation of the EGFR, and EGFR characteristic downstream signalling events were observed in response to stimulation with physiological concentrations of GPCR agonists such as the mitogens LPA and S1P as well as therapeutically relevant …
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Exploring Non-transgenic CRISPR-Cas9 gRNA Delivery Using Transactivation in Nicotiana benthamiana
… to be lost over time. The positive readout transactivation system developed in this thesis will be a valuable tool for future CRISPR development in plants. In addition, the data reported present opportunities for further exploration on potential delivery methods, spatial specificity of …
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Direct Reprogramming Of Fibroblasts Into Muscle Or Neural Lineages By Using Single Transcription Factor With Or Without Myod Transactivation Domain
… factors (Pax3 or NeuroD1) with the potent MyoD transactivation domain (MDA) that could facilitate radical acceleration of reprogramming into the desired cell type through chromatin modification compared to wild-type factors. Here, we showed that Pax3 can reprogram MEFs towards a myogenic lineage …
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Phosphorylation of Glucocorticoid Receptor tau1c Transactivation Domain Enhances Binding to CREB Binding Protein (CBP) TAZ2 and a Microfluidic, High Throughput Protein Crystal Growth Method for Microgravity
… receptor (GR) N-terminal domain (NTD) contains a transactivation domain (activation function 1; AF-1). Although GR AF-1 is phosphorylated, effects of GR phosphorylation upon AF-1 activity and cofactor recruitment are not clear. Most GR AF-1 activity is confined to an unstructured domain called …
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Ras signaling enhances the activity of C/EBPalpha to induce granulocytic differentiation by phosphorylation of serine 248
… sites. Ras signaling activates C/EBPa via the transactivation domain, because it enhances the transactivation function of a fusion protein containing a Gal4 DNA binding domain and the C/EBPa transactivation domain, and does not change C/EBPa DNA binding. Ras acts on serine 248 of the C/EBPa …
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Molecular mechanism of action of the glucocorticoid receptor:Role of ligand-dependent receptor phosphorylation and half-life in determination of ligand-specific transcriptional activity. : Contents Pages
… at S226 was shown to inhibit maximal transactivation and transrepression efficacy. Attempts to identify the kinases responsible for this interaction were inconclusive but suggested a combination of kinases is responsible for the in vivo phosphorylation of the hGR in these cells. …
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Mapping Domains for ZIC3 Molecular Function
… well characterised, yet details regarding its transactivation domain remain unknown. During embryonic development ZIC3 is involved in maintaining pluripotency of embryonic stem cells, formation of the left-right (L-R) axis and arrangement of visceral organs. Mutations in Zic3 in humans and …
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Mapping Domains for ZIC3 Molecular Function
… well characterised, yet details regarding its transactivation domain remain unknown. During embryonic development ZIC3 is involved in maintaining pluripotency of embryonic stem cells, formation of the left-right (L-R) axis and arrangement of visceral organs. Mutations in Zic3 in humans and …
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Asssessing the Liquid-Liquid Phase Separation Abilities of Eyes Absent Protein
… activity, and an intrinsically disordered “transactivation domain” (TAD) in the N-terminus. Despite wide sequence variation in human EYA1-4 TADs, with approximately 40% identity conserved vs. 77% identity conserved in the ED, all four EYA TADs were identified as potential drivers of …
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An investigation into the role of acetylation and ligand-dependent nuclear localisation in glucocorticoid receptor transcriptional regulation
… however the role of GR acetylation in transactivation is unclear.
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Structure-Activity Relationship and Mechanistic Studies on the Chemopreventive Activity of Dipyridamole and Its Analogues
… was shown to inhibit TPA-induced AP-1 transactivation. Inhibition of AP-1 transactivation suggests the involvement of mitogen-activated protein kinase (MAPK) signaling pathways which are upstream effectors of AP-1 transactivation, and so the involvement of MAPKs was assessed in this …
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Analysis of the interaction between the co-chaperone p23 and the aryl hydrocarbon receptor
… the known binding partner SRC-1. This AhR NΔ515 transactivation domain construct was used, along with amino terminal AhR deletion constructs AhR CΔ274 and AhR CΔ553, to attempt to elucidate the nature of the interaction between AhR and p23 in vitro.</p>
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Mapping of the repression domain and the subcellular localization of the ABF-1 protein
… repressor because it was able to prevent the transactivation abilities of E47 in HeLa cells and the region responsible was hypothesized to reside within the C-terminal portion. This study has further mapped the repression domain to the C-terminal portion bearing the bHLH domain. In addition, …
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Identification et caractérisation de nouveaux isoformes humains du gène Pax-5
… trait caractéristique d ’un domaine de transactivation. Les isoformes de Pax-5 sont présents dans les cellules mononucléaires du sang périphérique, dans les lignées de cellules B cancéreuses et non cancéreuses, ainsi que dans les cellules B des tissus lymphatiques. Les essais de …
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Frameworks for reprogramming early diverging land plants
… for expression of heterologous elements by transactivation which showed negligible levels of basal activity. It was possible to use this system for induction of gene expression in single cells. Finally, these new frameworks were applied to study the gametophytic meristem in Marchantia …
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Regulation of cellular glucose metabolism by HIV-1 infection
… suppresses viral replication and promoter level transactivation of the viral LTR. Next we sought to identify if glycolytic enzyme PKM2, that is also known to play a nonmetabolic dual role as a protein kinase regulating gene transcription has any effect on the transcription of HIV-LTR. Our study …
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