Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 788 for “"toxin"”.
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Toxin-membrane interactions of Pasteurella multocida toxin and homologous domains
Toxin-membrane interactions are poorly understood on the molecular level due to the inherent difficulty of crystallizing membrane protein complexes and the large size (>50 kDa) of most functional AB or MARTX protein toxins. Toxins can interact with membranes at three stages during intoxication: 1) …
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Untersuchungen zur Substratspezifität der ADP-Ribosyltransferasen Clostridium botulinum C2-Toxin und Clostridium perfringens Iota-Toxin
Clostridium perfringens Iota-Toxin und Clostridium botulinum C2-Toxin gehören zur Familie der binären Aktin-ADP-ribosylierenden Toxine. Die Toxine bestehen aus einer Enzymkomponente (ADP-Ribosyltransferase) und einer separaten Bindungs- und Translokationskomponente, die die Zellaufnahme vermittelt. …
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The Biochemistry of VapBC Toxin-Antitoxins
The VapBC toxin-antitoxin (TA) systems were first identified in 2005 and little is known about their contemporary biological function, despite the fact that VapBC TAs are the largest TA family and are widespread in bacteria and archaea (Arcus, Rainey, & Turner, 2005; Gerdes, Christensen, & …
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Anthrax toxin effects on B lymphocyte function
… a number of virulence factors of which, the two toxins are of great importance. Lethal toxin is a zinc metaloprotease that cleaves the N terminus of the mitogen-activated protein kinase (MAPK) kinase family 1-7, with the exception of MEK5. This kinase family is responsible for activating the …
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Factors Affecting Phytoplankton Biodiversity and Toxin Production
… survey of water quality, algal biodiversity, and toxin production in Southern California lakes, ponds, bays, and lagoons along the California coastline, in five counties from Santa Barbara to San Diego. Samples were analyzed for pH, electrical conductivity, total dissolved solids, dissolved …
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19F-NMR studies on anthrax toxin protective antigen
… one of three protein components of the anthrax toxin, an AB toxin (two-component protein complexes secreted by a number of pathogenic bacteria) secreted by Bacillus anthracis. PA is capable of undergoing several structural changes, including oligomerization to either a heptameric or octameric …
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Understanding gene expression with a pore forming toxin
… attack of low doses of a well-known pore forming toxin (staphylococcal α-hemolysin (αHL)) and to develop a new biotech application using the same protein.
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Cadmium, a toxin and nutrient for marine phytoplankton
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 1995.
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Sporulation and toxin formation in Bacillus sphaericus 1593
… on the growth, sporulation, and mosquito larval toxin formation by B. sphaericus 1593, were investigated in shaken flasks and a fermenter. The bacteria grew well at temperatures of 25 to 40°C, however, toxin-formation and sporulation were poor at temperatures above 30°C. Cell lysis became evident …
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Purification and characterization of Clostridium perfringens iota toxin
Clostridium perfringens type E iota toxin is implicated in some cases of fatal diarrhea in calves, lambs, and guinea pigs. A crossreacting "iota-like" toxin, produced by Clostridium spiroforme, is responsible for antibiotic-associated and weaning related enterotoxemias of rabbits. Antisera …
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Recombinant Mucins with Tailored Glycosylation as Bacterial Toxin Inhibitors
… mediated through the interactions of bacterial toxins with cell-surface receptors. Inhibition of these interactions has the potential to prevent the toxins from reaching their site of action, and thus, averting the subsequent toxin effects. Even though, multivalent inhibitors that engage in …
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Bacterial defense islands: CRISPR-Cas and toxin-antitoxin systems /
… of type I CRISPR-Cas and CRISPR-Cas associated toxin-antitoxin systems. The first part of this thesis focuses on fundamental aspects of multiprotein class 1 type I-E and I-F CRISPR-Cas effector complexes aiming to understand molecular mechanisms of target recognition and degradation using a …
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Investigations into the nature of the potato psyllid toxin
… yellows". The disease is caused by a phytotoxin produced by the potato psyllid that is systemic and causes many morphological changes in the host plant which can lead to crop loss. The effects of potato psyllid feeding on the yield of several varieties of potato, tomato and pepper were …
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Genetic and Chemical Genetic Approaches to Shiga Toxin Inhibition
Infection with Shiga toxin-producing bacteria can place patients at risk of developing hemolytic uremic syndrome, a toxemic condition characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. Though hemolytic uremic syndrome remains the leading cause of acute renal failure in …
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Computational Approaches To Anti-Toxin Therapies And Biomarker Identification
… describes the fundamental study of two bacterial toxins with computational methods, the rational design of a potent inhibitor using molecular dynamics, as well as the development of two bioinformatic methods for mining genomic data. </p> <p>Clostridium difficile is an opportunistic bacillus which …
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