Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 78 for “"therapeutic response"”.
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The Role of Nutrient Availability in Therapeutic Response of Leukemia
<p>Tumor environment influences the response to anti-cancer therapy, but which extracellular nutrients impact drug sensitivity is largely unknown. In this work, we used functional genomics to identify metabolic modifiers of the response to L-asparaginase (ASNase), a therapy that depletes plasma …
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Functional Drivers of Therapeutic Response in Diffuse Large B Cell Lymphoma
… hampering efforts at designing effective therapeutic agents. The last major change in frontline therapy for DLBCL came in 1997 with the addition of rituximab into widespread clinical use. Much effort has been put forth to identify new therapeutic agents in DLBCL, but these have been …
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Dissecting the Role of ATRX in Soft Tissue Sarcoma Development and Therapeutic Response
… However, the role of ATRX in the development and response to cancer therapies in soft tissue sarcoma remains poorly understood. Here, we developed a primary mouse model of soft tissue sarcoma and studied the effect of Atrx deletion on tumor development and therapeutic response. Our findings …
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AMP-ACTIVATED PROTEIN KINASE AND ITS ROLE IN THERAPEUTIC RESPONSE IN ACUTE MYELOID LEUKEMIA
Acute myeloid leukemia (AML) is an aggressive cancer of the bone marrow characterized by poor prognosis and resistance to chemotherapy. The way in which cancerous cells are able to metabolically adapt to various physiological and metabolic stressors allows them to thrive and proliferate. A leading …
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Combinatorial Modulation of Multiple Signaling Pathways to Gain Therapeutic Response in Breast and Prostate Cell Carcinomas
… cyto-protective pathways can be activated in response to growth factor stimulation, toxic insult and radiation. In our studies, we utilized novel drug combinations with and without radiation to enhance breast & prostate tumor cell death both in vitro and in vivo. Previous studies from our …
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The Physiological Effects of CD38 in Prostate Cancer: A multifunctional NAD'ase capable of regulating cell metabolism, gene expression, and therapeutic response
… prostate cancer (PCa) cell metabolism and therapeutic response. Prostate specific silencing of CD38 is inversely correlated with prostate cancer progression and results in increased availability of NAD+. Increased NAD+ resulting from CD38 silencing contributes to changes in the metabolic …
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Quantification of Major BCR-ABL1 Fusion Gene Transcripts for Monitoring Therapeutic Response to Tyrosine Kinase Inhibitors in Chronic Myelogenous Leukemia; Comparison of LightCycler t(9;22) Quantification Kit and BCR-ABL1 Mbcr IS-MMR Dx Kit.
BACKGROUND: CML is in >90% of cases characterized by the presence of the Philadelphia chromosome (Ph) and the corresponding fusion gene, BCR-ABL1. For disease monitoring, standardize BCR-ABL1 quantification and International Scale (IS) has been suggested, and this study is to compare IS-based …
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Investigating the efficacy and mechanism of action of mesenchymal stromal cell therapy in burn wound healing
… wound healing. Which source of MSC is therapeutically superior has not been well established, especially in large clinically relevant animal models. We therefore investigated the efficacy of Bone marrow-MSC (BM-MSC) and Adipose-MSC (AD-MSC) in the treatment of burn wounds in a large …
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Investigation of an atypical protoporphyric family in South Africa
… of protoporphyrin in its zinc chelated form, a therapeutic response to iron supplementation, and an absence of mutations in the ferrochelatase gene or haplotype markers associated with erythropoietic protoporphyria. We have reviewed clinical data from this family, established a ferrochelatase …
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Investigating the Anti-Melanoma Activity of Combinatorial Paclitaxel and MEK Inhibitor
… drugs do not produce a satisfactory therapeutic response for the treatment of late stage melanoma. Nanomedicine is a potent tool for clinicians to circumvent many of the existing shortcomings in cancer therapy. Combination of more than one drug may maximise the therapeutic response …
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Mechanisms of microenvironmental paracrine signaling in cancer chemoresistance
… the tumor microenvironment and its impact on therapeutic response. The specific cell types and microenvironment factors that influence chemoresistance, how therapy induced damage of the microenvironment changes these factors and the mechanisms by which the microenvironment contributes to …
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Resolving Intra-Tumoral Heterogeneity of Breast Cancer Using Single-Cell Multi-Omics
… how intra-tumoral heterogeneity (ITH) influences therapeutic response and drives tumor evolution remains a central challenge in cancer biology. Here, we leverage single-cell multi-omics technologies to dissect the cell states and gene expression programs underlying breast cancer heterogeneity, …
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Investigating the utility of blood borne oncological biomarkers in solid tumours: glioma and melanoma
… epigenetic regulatory mechanisms implicated in therapeutic resistance which is prevalent in melanoma brain metastasis. Specifically, this research work sought to determine whether somatic mutations identified in the plasma samples of patients with glioma were identical or representative of the …
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Responding to suicidal ideations in online peer support groups
… in three ways: the frequency of pro-suicide response, the frequency of non-civil and impolite response, and the frequency of therapeutic response strategies. The study begins with a literature review that addresses how the Internet may affect peer support to those who suffer from suicidal …
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AXL Targeting Restores PD-1 Blockade Sensitivity of STK11/LKB1 Mutant NSCLC Through Expansion of TCF1+ CD8 T Cells
… cancer (NSCLC) are associated with poor patient responses to immune checkpoint blockade (ICB) for unknown reasons. We found that introduction of a Stk11/Lkb1 (L) mutation into murine lung adenocarcinomas driven by mutant Kras and Trp53 (KP) resulted in an ICB refractory syngeneic KPL tumor. …
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Analysis of the Repeated Measurement Data using the Hierarchical Clustering and Nonlinear Regression Methods in Asthma Pharmacogenetic Study
… examined several analytic methods for predicting therapeutic response to drug in Korea asthmatics and tried to develop a clinical model to predict the drug response to asthma drug. BACKGROUND: Long acting β2-agonists (LABA) is the most powerful bronchodilator and inhaled corticosteroid (ICS) was …
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Development of Implantable Optical Fibers for Immunotherapeutics Delivery and Tumor Impedance Measurement
… such as severe toxicities and moderate patient-response rates. None of the current delivery strategies, including local administration aiming to avoid systemic toxicities, can sustainably supply drugs over the course of weeks; adjustment of drug dose, either to lower systemic toxicities or to …
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Translational phosphoproteomics methods to identify biomarkers and novel therapeutic targets
… mediated signaling networks in tumors can inform therapeutic interventions. Additionally, analysis of phosphoproteome in response to drug candidates can help identify biomarkers for therapeutic response as well as lend direct insights into potential adaptive resistance mechanisms. However, …
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Non-conventional Regulation of Treg Development and Function
… treatment. Hence, the development of new therapeutics is an utmost priority. Tregs are vital in maintaining immunological tolerance and preventing inappropriate inflammatory responses. Despite having no obvious functional defects, Tregs are unable to regulate inflammation in human IBD …
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Immune Cell Subsets Direct or Antagonize Tumor Immunity: Promotion of TH1 Responses in Tumor Vaccination
… to tumor-burdened host (TBH) memory T cell responses (or the lack thereof). We demonstrate tumor growth impairs T cell activation by modulating CD4+ T cell infiltration and systemic CD44 and CD62L activation marker expression, and by downregulating TBH TH1 cytokine production by splenic CD4+ …
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