Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"tandem duplication"”.
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A Broad Analysis of Tandemly Arrayed Genes in the Genomes of Human, Mouse, and Rat
Tandemly arrayed genes (TAG) play an important functional and physiological role in the genome. Most previous studies have focused on individual TAG families in a few species, yet a broad characterization of TAGs is not available. We identified all the TAGs in the genomes of human, chimp, mouse, …
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Genomic Instability and Gene Dosage Obscures Clues to Virulence Mechanisms of F. tularensis species
… chemical mutant TIGB03 revealed a large 75.5 kb tandem duplication flanked by transposable elements, while the genome of a virulent Clone01 (vir-[wbtK+]TIGB03-C1) lost one copy of the 75.5 kb tandem duplicated region but gained a tandem duplication of another large 80kb region that contains a …
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Genome reconstruction and combinatoric analyses of rearrangement evolution
… combinatorial properties associated with gene duplications. We applied graph theory to the problem of reconstructing the final cancer genome sequence; additionally, we developed an algorithmic approach for the reconstruction of a multi-step evolution consistent with read coverage and paired end …
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Studies on signaling pathways induced by FLT3, an important oncogene in AML
… progenitor cells. FLT3-ITD (internal tandem duplication) and D835 mutations are found in approximately 30% and 7% of Acute Myeloid Leukemia (AML) patients respectively, and correlate with a poor prognosis, thus making the mutated receptor a potential therapeutic target. FLT3 mutations …
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Cytogenetically normal acute myeloid leukaemia at a single centre in South Africa
… (NPM1), fms-like tyrosine kinase internal tandem duplication (FLT3-ITD) and CCAAT/enhancer binding protein alpha (CEBPα) mutations in accordance with the ELN 2017 guidelines. Methods A review of cytogenetic results for all adult de novo AML cases diagnosed at Groote Schuur Hospital between …
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Redox biology of myeloid leukaemias
Internal tandem duplication of FMS-like receptor tyrosine kinase (FLT3-ITD) has been associated with an aggressive AML phenotype. FLT3-ITD expressing cell lines have been shown to generate increased levels of reactive oxygen species (ROS) and DNA double strand breaks (dsbs). However, the molecular …
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Integrin α2 and Akt in early hematopoiesis
… ability of FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) signaling in murine stem and progenitor cells. Prospective isolation of more homogenous stem and progenitor cell populations in human and understanding the instrinsic regulation of HSC homeostasis will give important …
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THE INHIBITOR-OF-APOPTOSIS PROTEIN SURVIVIN INCREASES P34CDC2 PHOSPHORYLATION AND ENHANCES CELL SURVIVAL AND PROLIFERATION BY PROTECTING THE WEE1 KINASE FROM DEGRADATION BY CASPASE-3
… survival. BaF3 cells transduced with Internal Tandem Duplication (ITD) mutations of the Flt3 receptor that results in increased Survivin levels, also contained increased levels of Tyr15 phosphorylated Cdc2. In BaF3 cells over-expressing wt-Survivin, 2-fold higher levels of Wee1 protein were …
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Genetic and molecular characterization of origins of replication from beta-lactamase-producing plasmids of Neisseria gonorrhoeae.
… Asia-type plasmid which contains an endogenous tandem duplication of 1,883 bp. The direct repeat DR-2 is implicated in this duplication. Branch-point analysis by electron microscopy indicated that the Asia-type plasmid contains three origins of replication, named ori1, ori2, and ori3. Although …
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Concomitant Inhibition of Flt3 and Mcl-1 In Flt3 Mutated Acute Myeloid Leukemia
… processes in hematopoietic cells. FLT3 internal tandem duplication (ITD) mutations are common in leukemia and have been observed in up to a third of newly diagnosed AML patients. FLT3-ITD have been implicated as a driver mutation partly responsible for disease progression and associated with …
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Characterisation of the effects and mechanism of action of rapamycin and genistein on acute myeloid leukemia using high-throughput techniques
… MV4-11 cells, which carry the FLT3-ITD (Internal Tandem Duplication) mutations. However, GEN had potent anti-leukemic effects on the HL-60 cells too, in spite of them possessing the wild-type version of the gene. A purely proteomic-based approach, using the 8-plex iTRAQ strategy, was employed to …
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KIT Mutations in Australian Canine Mast Cell Tumours and Correlations with Patient Prognostic Factors
… gene, KIT. Dogs with MCTs harbouring an internal tandem duplication (ITD) within exon 11 of the extracellular regulatory domain of KIT are more likely to respond to treatment with tyrosine kinase inhibitors. Conversely, MCTs with mutation of the intracellular tyrosine kinase domain are resistant …
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Algorithms for analyzing complex structural variations in cancer genomes
… two mechanisms, breakage-fusion-bridge (BFB) and tandem duplication (TD), for recurrent focal amplifications and found different frequently focal amplified regions have different enrichment of specific tumor types. We proposed a new pan-cancer classification method, for the first time utilizing SV …
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Events that shape genomes
… were found to have increased levels of non-tandem duplication within the genome as well as on going transposable element activity when compared to C. herrei. Xerohpyta humilis is a desiccation tolerant plant. In order to further facilitate research into how this is possible, the genome was …
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Metabolic engineering of yeast for xylose uptake and fermentation
… was used to screen the library, revealing the tandem duplication of XYLA in the H131E5-XYLA31 genome. The structure of XYLA integration, coupled with qPCR, DNA/RNA blotting, and enzyme activity assay results, suggests that the high expression level of XI is a major recombination event during …
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Properties of the Merozygotes Associated with a Sulfonamide-Resistant Mutation in Pneumococcus
… around the c locus; the other involves a duplication in tandem of the c region. An attempt was made to distinguish the models on the basis of physical properties of the DNA of the strain: buoyant density, affinity for methylated albumin-kieselguhr, and ability to become inactivated by …