Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"syntaxin"”.
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Syntaxin-3 mediates baseline and stimulated mucin secretion
… VAMP, and the target-SNAREs SNAP and Syntaxin. Coiling of the complex fuses the granule and plasma membranes to release mucins into the extracellular space. The VAMP and SNAP isoforms mediating baseline and stimulated secretion are known, but the Syntaxin (Stx) isoform remains …
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Regulation of Exocytosis by Syntaxin 4-Munc18c Complexes
… Both GSIS and glucose uptake are regulated by Syntaxin 4 (Syn4)-Munc18c complexes. Importantly, reports link obesity and Type 2 diabetes in humans with changes in protein levels of Munc18c and Syn4; yet the molecular mechanisms underlying this requirement remain unclear. The central hypothesis …
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Regulation of glucose homeostasis by MUNC18c and syntaxin 4
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Der Syntaxin 1-Cluster - Organisation und Dynamik einer supramolekularen Struktur der Plasmamembran
… uniforme Verteilung zeigt, ist das SNARE-Protein Syntaxin 1, von dem bekannt ist, dass es in sogenannten Clustern aufkonzentriert vorkommt, an denen sekretorische Vesikel bevorzugt docken und mit der Plasmamembran verschmelzen. Mittels STED-Mikroskopie wurde in Zusammenarbeit mit der Abteilung …
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Syntaxin 6- and Microtubule- Mediated Intracellular Trafficking Contributes to Golgi and Nuclear Translocation of Egfr
… with dynein and fuses with the Golgi through syntaxin 6 (Syn6)-mediated membrane fusion. We also demonstrate that the Golgi translocation of EGFR is necessary for its consequent nuclear translocation and transcriptional activity. Interestingly, foreign protein such as bacterial cholera toxin, …
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The role of SNAREs in chlamydial infection: Syntaxin 4 and SNAP-23 disrupt lipid droplets homeostasis
As clamídias são bactérias de Gram negativo, intracelulares obrigatórias que infetam células eucarióticas. O seu ciclo de replicação é bifásico, com uma forma extracelular infeciosa e uma forma intracelular replicativa. Dentro da célula, a replicação ocorre exclusivamente no interior de vacúolos, …
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Re-localization of SNARE proteins in mouse sperm prior to the acrosome reaction
… than 60 members. A member of the SNARE family, syntaxin, is found on the sperm plasma membrane while synaptobrevin, is found on the outer acrosomal membrane. During the sperm acrosome reaction, the outer acrosomal membrane fuses at hundreds of points with the overlying plasma membrane, resulting …
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Regulation of SNARE function during sperm capacitation to promote the acrosome reaction
… phosphorylation of proteins in SNARE complexes, syntaxin and associated proteins were immunoprecipitated with a syntaxin antibody and subsequently separated by SDS-PAGE. Samples were not boiled prior to SDS-PAGE to maintain the integrity of the SNARE complex. To detect changes in total …
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Regulation of SNARE-dependent fusion in an in vitro system
… protein Munc18c and the SNARE proteins VAMP2 and syntaxin 4. The use of pull-down assays revealed the novel fact that Munc18c interacts not only with the t-SNARE syntaxin 4 but also with the v-SNARE VAMP2 via its SNARE motif. The SM:v-SNARE interaction was disrupted by the presence of syntaxin 4 …
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Structural and Functional Studies of Munc18 and SNARE Proteins
… vesicle fusion due to its tight binding to syntaxin-1. The strict requirement of Munc18-1 for release is illustrated by the observation that, in mice, deletion of Munc18-1 abolished neurotransmitter release completely. Munc18-1 binds to the closed conformation of syntaxin-1 as well as to …
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Protein-Protein Interactions That Regulate Neurotransmitter Release From Retinal Ribbon Synapses
… factor attachment protein receptor) syntaxin 1A that is found in conventional synapses of the nervous system. In contrast, ribbon synapses of the mammalian retina contain the related isoform, syntaxin 3B. Given that SNARE proteins play an important role in neurotransmitter release in …
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Unraveling the Molecular Mechanisms of Munc18 and Munc13 in Mast Cell Exocytosis
… mast cells partly through regulating its cognate syntaxin partners such as syntaxin-3 and -11 for their protein level and trafficking. Independent knockdowns of syntaxin-3 and -11 demonstrate that syntaxin-3 is the key cognate syntaxin whose level and intracellular localization are regulated by …
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Unraveling the Role of SNARE Interactions in Neurotransmitter Release
… synaptobrevin and the plasma membrane proteins syntaxin 1 and SNAP-25, which are collectively known as SNAREs and form a tight complex (the core complex). The assembly of the core complex may mediate membrane fusion. Complexin is a highly conserved cytoplasmic protein that binds tightly to the …
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Charakterisierung der endosomalen Qb-SNAREs Vti1a und Vti1b
… nachgewiesen werden, dass Vti1a zusammen mit Syntaxin 6 (Qc), Syntaxin16 (Qa) und VAMP4 (R) einen Komplex bildet. Vti1a-defiziente Mäuse sind lebensfähig und fertil. Untersuchungen der Aktivitäten von lysosomalen Enzymen in Geweben von Vti1a-defizienten Tieren ergaben normale Werte, was auf …
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Development of Methods for the Study of Phosphoproteins
… with a MonoTip® TiO Pipette Tip. Analysis of syntaxin 1a phosphorylation by AMPK (AMP-activated protein kinase) was done by peptide level mapping for potential phosphopeptides after its unsuccessful trial with enrichment using the MonoTip® TiO Pipette Tip. Several criteria such as existence of …
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Insights into the Functions of Munc18-1 in Neurotransmitter Release
… neurons includes Munc18-1 and the SNARE proteins syntaxin-1, SNAP-25 and synaptobrevin. The SNAREs form tight SNARE complexes that bring the vesicle membrane and plasma membrane into close proximity and provide forces to induce membrane fusion. Munc18-1 is essential because deletion of Munc18-1 in …
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The Impact of Calcium Binding Protein 5 (CaBP5) on Synaptic Vesicle Dynamics in Rod Bipolar Cells in the Retina
… SNAP25, synaptobrevin, and the retina-specific syntaxin isoform, syntaxin-3B. Syntaxin-3B can be phosphorylated at T14 via calcium/calmodulin dependent protein kinase II (CaMKII) in a calcium-dependent manner. Given its structural similarities to calmodulin (CaM), CaBP5 may act on CaM effectors …
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Characterization of XV7 and XV9 cDNA clones which confer osmotolerance to Eschericia coli
… similarity between XV7 and the mammalian syntaxin-like protein kinase receptor shows that XV7 may function similar to that of animal protein kinases. The syntaxin-like protein kinase receptor was recently entered into the Genbank (Thoreau, unpublished), therefore not much is known about …
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Biophysikalische und thermodynamische Charakterisierung der neuronalen SNARE-Komplexbildung
… die plasmamembranständigen Proteine SNAP-25 und Syntaxin einen Akzeptorkomplex für das in der Vesikelmembran sitzende Synaptobrevin aus. Man geht davon aus, dass sich aufgrund dieser Komplexbildung die Membranen annähern und so letztendlich deren Fusion induziert wird. Der genaue Ablauf dieser …
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Dynamic changes in the localization of synapse associated proteins during development and differentiation of the mammalian retina
… membrane associated proteins SNAP-25 and Syntaxin, to characterize their spatio-temporal distribution during retinal differentiation and in the mature retina;The vertebrate retina has a laminar organization consisting of three cellular layers separated by two synaptic layers, the inner …
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